Sep 8, 2009

Potential vascular actions of 2-methoxyestradiol

Trends in Endocrinology and Metabolism : TEM
Raghvendra K Dubey, Edwin K Jackson

Abstract

2-Methoxyestradiol (2-ME) is a biologically active metabolite of 17beta-estradiol that appears to inhibit key processes associated with cell replication in vitro. The molecule has been suggested to have potent growth-inhibitory effects on proliferating cells, including smooth muscle cells and endothelial cells, and may be antiangiogenic. Because of these potential roles for 2-ME, its lack of cytotoxicity and low estrogenic activity, we hypothesize that 2-ME could be a valuable therapeutic molecule for prevention and treatment of cardiovascular diseases. Whether 2-ME is as effective in vivo as it is in vitro at modulating vascular processes remains controversial. Here we discuss recent developments regarding mechanisms by which 2-ME might regulate vascular activity and angiogenesis and speculate on the therapeutic implications of these developments.

Mentioned in this Paper

Muscle, Smooth, Vascular
Metabolic Process, Cellular
Biochemical Pathway
COMT gene
Angiogenic Process
Enzymes, antithrombotic
2-Mercaptoethanol
Vascular Endothelial Cells
Caspase-3
Panzem

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