Potentially inappropriate medications in older adults living with HIV.

HIV Medicine
B López-CentenoJ Berenguer

Abstract

We assessed the prevalence of potentially inappropriate medication (PIM) among older (≥ 65 years) people living with HIV (O-PLWH) in the region of Madrid. We analysed the dispensation registry of community and hospital pharmacies from the Madrid Regional Health Service (SERMAS) for the period between 1 January and 30 June 2017, looking specifically at PIMs according to the 2019 Beers criteria. Co-medications were classified according to the Anatomical Therapeutic Chemical (ATC) classification system. A total of 6 636 451 individuals received medications. Of these individuals, 22 945 received antiretrovirals (ARVs), and of these 1292 were O-PLWH. Overall, 1135 (87.8%) O-PLWH were taking at least one co-medication, and polypharmacy (at least five co-medications) was observed in 852 individuals (65.9%). A PIM was identified in 482 (37.3%) O-PLWH. Factors independently associated with PIM were polypharmacy [adjusted odds ratio (aOR) 7.08; 95% confidence interval (CI) 5.16-9.72] and female sex (aOR 1.75; 95% CI 1.30-2.35). The distribution of PIMs according to ATC drug class were nervous system drugs (n = 369; 28.6%), musculoskeletal system drugs (n = 140; 10.8%), gastrointestinal and metabolism drugs (n = 72; 5.6%), cardiovascular ...Continue Reading

References

Jan 26, 2008·International Journal of Clinical Pharmacology and Therapeutics·P GallagherD O'Mahony
Apr 29, 2010·Current HIV/AIDS Reports·Amy C Justice
Oct 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Giovanni GuaraldiFrank Palella
Nov 12, 2013·Journal of Women's Health·Marie ManteuffelAmy Steinkellner
May 15, 2015·European Journal of Clinical Pharmacology·Anna Renom-GuiterasPetra A Thürmann
Sep 27, 2015·European Journal of Clinical Pharmacology·Khedidja HednaStaffan Hägg
Mar 29, 2018·European Journal of Clinical Pharmacology·Fabiane Raquel MotterVera Maria Vieira Paniz
Jan 30, 2019·Journal of the American Geriatrics Society·UNKNOWN By the 2019 American Geriatrics Society Beers Criteria® Update Expert Panel
Jun 4, 2019·Expert Review of Clinical Pharmacology·Catia Marzolini, Françoise Livio
Aug 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Beatriz López-CentenoJuan Berenguer
Oct 18, 2019·Therapeutic Advances in Drug Safety·Françoise Livio, Catia Marzolini
Dec 23, 2019·European Journal of Clinical Pharmacology·José-Ramón BlancoUNKNOWN Gesida and SEFH

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Citations

Dec 7, 2020·The Journal of Antimicrobial Chemotherapy·Françoise LivioUNKNOWN Swiss HIV Cohort Study
Apr 30, 2021·Expert Opinion on Drug Metabolism & Toxicology·Andrea CalcagnoStefano Bonora
Apr 24, 2021·British Journal of Clinical Pharmacology·Andrea CalcagnoStefano Bonora

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