Potentially inappropriate prescribing of drugs in elderly patients on chronic hemodialysis treatment


Clinical Nephrology
Gorana Nedin RankovićDane Krtinić

Abstract

The aim of this study was to determine the prevalence of potentially inappropriate drug prescription (PIP) in older patients who were on chronic hemodialysis treatment and to explore the factors that lead to PIP. The study was performed at the Department of Nephrology, Clinical Center Niš, Serbia. It included patients who were 65 years old and older who suffered from the end-stage of kidney failure and were treated by hemodialysis. Univariate and subsequent multivariate logistic regression was used to analyze risk factors for PIP or omission (PPO) according to the STOPP and START criteria. The study included 83 patients. According to the START criteria, PPO was found in 18 (22%) patients, and 32 (39%) patients experienced PIPs according to the STOPP criteria. The following factors were associated with PIP according to the START criteria: a number of comorbidities, reading the patient leaflet, and having the habit of drinking coffee. According to the STOPP criteria, polypharmacy was associated with PIP (OR = 1.287, p = 0.021): each additional drug increased the risk of potentially inadequate medications (PIM) by 28.7%. Adequate consideration of potential risk factors, as well as the implementation of valid criteria for assessmen...Continue Reading

Citations

Mar 1, 2020·Research in Social & Administrative Pharmacy : RSAP·Inge R F van Berlo-van de LaarFrank G A Jansman

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