Potentially inappropriate use of benzodiazepines and z-drugs in the older population-analysis of associations between long-term use and patient-related factors

PeerJ
Aliaksandra MokharUwe Verthein

Abstract

The long-term use of benzodiazepines (BZD) and z-drugs in older populations is associated with a variety of sociodemographic and health-related factors. Recent studies reported that long-term BZD and z-drugs use is associated with increased age, female sex, and severe negative psychological (e.g., depression) and somatic (e.g., chronic disease) factors. The current study explores the sociodemographic and health-related factors associated with long-term BZD and z-drugs use in the elderly. We conducted a cross-sectional survey among randomly selected patients of one health insurance plan ("AOK North-West") with BZD and z-drugs prescriptions in the past 12 months. The sample was stratified by appropriate German prescription guidelines (yes vs. no) and age (50-65 vs. >65 years). To examine the association of selected sociodemographic and psychological variables (e.g., sex, employment status, quality of life, depression) with long-term use, a binary logistic regression analysis was conducted. In total, data from 340 patients were analyzed. The mean age was 72.1 (SD = 14.5) years, and the most commonly used substances were zopiclon (38.1%), oxazepam (18.1%), and lorazepam (13.8%). The mean defined daily dose (DDD) was 0.73 (SD = 0.47...Continue Reading

References

Jan 1, 1996·European Journal of Clinical Pharmacology·N MagriniN Montanaro
Aug 28, 1998·Journal of Psychosomatic Research·J S Carpenter, M A Andrykowski
Feb 19, 2000·International Journal of Geriatric Psychiatry·T González-SalvadorC Steele
Jan 6, 2001·Acta Psychiatrica Scandinavica·W J NajaC Baddoura
Aug 19, 2003·CNS Drugs·Robert G Cumming, David G Le Couteur
Aug 28, 2003·TheScientificWorldJournal·Søren Ventegodt, Joav Merrick
Mar 9, 2004·Journal of Psychiatric Research·Dalva PoyaresSergio Tufik
Sep 3, 2004·Sleep Medicine·Charles M MorinFrançois Bernier
Jan 12, 2005·The Journal of Applied Psychology·Frances McKee-RyanAngelo J Kinicki
Mar 17, 2005·JAMA : the Journal of the American Medical Association·Daniela FialováUNKNOWN AdHOC Project Research Group
Oct 1, 2005·International Review of Psychiatry·C Ineke Neutel
Feb 8, 2006·Journal of the American Geriatrics Society·Shelly L GrayDave M Buchner
Apr 25, 2007·Alcoholism, Clinical and Experimental Research·Katharine A BradleyDaniel R Kivlahan
Aug 11, 2007·International Clinical Psychopharmacology·Sylvie PetitjeanGerhard A Wiesbeck
May 9, 2009·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Nancy C Cheak-ZamoraTimothy D McBride
Aug 8, 2009·British Journal of Clinical Pharmacology·Danijela GnjidicSarah N Hilmer
Jul 27, 2010·Aging & Mental Health·Sarah-Gabrielle BelandYola Moride
Nov 20, 2010·Journal of Evaluation in Clinical Practice·Cornelia MahlerJoachim Szecsenyi
Apr 7, 2011·Current Drug Abuse Reviews·Dieter Henkel
Jun 18, 2011·Social Psychiatry and Psychiatric Epidemiology·Peter ButterworthMargaret Kelaher
Jul 1, 2011·Addiction·Malcolm Lader
Mar 26, 2013·Nordic Journal of Psychiatry·Trond NordfjærnRolf Gråwe
Sep 27, 2013·Journal of Psychopharmacology·David S BaldwinSue Wilson
Jul 9, 2014·Drug and Alcohol Dependence·Fabio LugoboniGiovanni Addolorato
Dec 18, 2014·JAMA Psychiatry·Mark OlfsonMichael Schoenbaum
Sep 4, 2015·Journal of Affective Disorders·Sakina J RizviSidney H Kennedy
Oct 9, 2015·Journal of the American Geriatrics Society·UNKNOWN By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel
Aug 29, 2016·The Psychiatric Quarterly·Michel PerreaultJean Caron
Jan 6, 2017·International Journal of Environmental Research and Public Health·Stefano TamburinFabio Lugoboni
Jul 26, 2017·Therapeutic Advances in Psychopharmacology·Louis JacobKarel Kostev

❮ Previous
Next ❯

Citations

Apr 13, 2019·Aging & Mental Health·Virginie Proulx-TremblaySébastien Grenier
Feb 8, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Shin-Chiao TienChun-Chi Hsu
Oct 31, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Clément MathieuAntoine Pariente

❮ Previous
Next ❯

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved