Potentially Lethal Ventricular Arrhythmias and Heart Failure in Arrhythmogenic Right Ventricular Cardiomyopathy: What Are the Differences Between Men and Women?

JACC. Clinical Electrophysiology
Yoshitaka KimuraKengo Kusano

Abstract

The aim of this study was to assess sex-related differences in sporadic cases of arrhythmogenic right ventricular cardiomyopathy (ARVC). Previous studies have suggested male predominance in ARVC. However, the impact of sex on the heterogeneous clinical profile and prognosis of ARVC were not fully recognized. The study population included 110 patients with ARVC who fulfilled the revised Task Force criteria (median age 48 years [interquartile range (IQR): 36 to 57 years]). All patients were sporadic cases without family history of ARVC. Male patients had a 3:1 predominance (75%). Ninety-seven patients (88%) were considered to have "definite" ARVC based on revised Task Force criteria. At the initial evaluation, there were no significant sex-related differences in age, 12-lead electrocardiogram findings, late potentials by signal-averaged electrocardiogram, left ventricular ejection fraction, or right ventricular ejection fraction. During a median follow-up of 10.0 years (IQR: 5.2 to 15.6 years), 18 patients died from cardiac causes. Kaplan-Meier analysis, considering patients' lives since birth, revealed that male patients had a significantly higher risk of ventricular tachycardia/ventricular fibrillation than did female patients ...Continue Reading

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Citations

Jun 13, 2018·Journal of Cardiovascular Electrophysiology·Weijia WangHugh Calkins
Nov 22, 2017·Circulation·Hugh CalkinsFrank Marcus
Oct 26, 2018·Annual Review of Medicine·Cynthia A James, Hugh Calkins
May 16, 2020·Journal of the American Heart Association·Wolfgang PollerSabine Klaassen
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Mar 15, 2019·Cardiology·Lourdes VicentManuel Martinez-Sellés
Dec 12, 2021·European Heart Journal·Deepthi RajanJacob Tfelt-Hansen

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