Potentials of combining nanomaterials and stem cell therapy in myocardial repair

Nanomedicine
Yang YaoQiang Peng

Abstract

Cardiac diseases have become the leading cause of death worldwide. Developing efficient strategies to treat such diseases is of great urgency. Stem cell-based regeneration medicine offers a novel approach for heart repair. However, low retention and poor survival rate of engrafted cells limit its applications. Nanomaterials have shown great potentials in addressing above issues due to nanoparticles-bio interactions. Therefore, combining nanomaterials and stem cell therapy is of great interest and significance for heart repair. Herein, we provide a comprehensive understanding of the applications of four types of nanomaterials (nanogels, polymeric nanomaterials, inorganic nanomaterials and exosomes) in stem cell therapy for myocardial repair. In addition, we launch an initial discussion on current problems and more importantly, possible solutions for myocardial repair.

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Citations

Mar 22, 2019·Pharmaceutical Nanotechnology·Le HongQiang Peng
Aug 23, 2020·International Journal of Molecular Sciences·Saltanat SmagulArman Saparov
Aug 19, 2020·Current Drug Delivery·Shuyuan LiYushun Dou

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