PMID: 6112485May 23, 1981Paper

Potentiating action of rifampicin and isoniazid against Leishmania mexicana amazonensis

Lancet
W PetersA F Leão

Abstract

The treatment of the complex of diseases known as leishmaniasis, caused by infection with protozoal parasites, is often unsatisfactory. The response to chemotherapy depends not only on the species of infecting Leishmania but also on the immune reactions of the host. This creates difficulties in evaluating any new drug in clinical trials. In a Brazilian patient with diffuse cutaneous leishmaniasis, which classical antileishmanial drugs had failed to cure, antituberculous therapy of an intercurrent mycobacterial infection produced a striking remission of the leishmanial skin lesions. Subsequent studies in mice infected with the strain of L. mexicana amazonensis isolated from this patient showed that para-aminosalicylic acid was inactive and both rifampicin and isoniazid had only a moderate beneficial action. However, a pronounced degree of potentiation was observed when rifampicin and isoniazid were administered in combination. Clinical trials of this combination are recommended in further patients, as well as experimental studies on other antimycobacterial agents, alone and in various combinations.

References

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Citations

Jan 1, 1985·Zeitschrift Für Parasitenkunde·M A MillgramJ Shlomai
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·L Weinrauch, J El-On
Jul 25, 1981·Lancet·S KobayashiA Kumagai
Mar 1, 2003·Clinics in Dermatology·Nikolai Tsankov, Irena Angelova
Aug 1, 1996·International Journal of Dermatology·T M TallabA Jamal
Jan 1, 1993·Antimicrobial Agents and Chemotherapy·A B MorrisM Sands
Jan 1, 1983·International Journal of Dermatology·R LivshinZ Even-Paz
Nov 1, 1994·Journal of the American Academy of Dermatology·A B Koff, T Rosen
Mar 2, 2018·PLoS Neglected Tropical Diseases·Dalila Y MartínezMarleen Boelaert
Jan 1, 1987·International Journal of Dermatology·R LivshinJ el-On
Oct 1, 1986·Tropical Doctor·C P Thakur
Dec 1, 1986·International Journal of Dermatology·H Chong
Oct 1, 1986·Annals of Tropical Medicine and Parasitology·J el-OnL F Schnur
Oct 1, 1989·Annals of Tropical Medicine and Parasitology·A T EvansR A Neal
Apr 1, 1984·Annals of Tropical Medicine and Parasitology·J El-OnC L Greenblatt
Sep 2, 2014·Parasites & Vectors·Hamida Al-DwibeAhmad Amro

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