Potentiating paired corticospinal-motoneuronal plasticity after spinal cord injury

Brain Stimulation
Karen L BundayMonica A Perez

Abstract

Paired corticospinal-motoneuronal stimulation (PCMS) increases corticospinal transmission in humans with chronic incomplete spinal cord injury (SCI). Here, we examine whether increases in the excitability of spinal motoneurons, by performing voluntary activity, could potentiate PCMS effects on corticospinal transmission. During PCMS, we used 100 pairs of stimuli where corticospinal volleys evoked by transcranial magnetic stimulation (TMS) over the hand representation of the primary motor cortex were timed to arrive at corticospinal-motoneuronal synapses of the first dorsal interosseous (FDI) muscle ∼1-2 ms before antidromic potentials were elicited in motoneurons by electrical stimulation of the ulnar nerve. PCMS was applied at rest (PCMSrest) and during a small level of isometric index finger abduction (PCMSactive) on separate days. Motor evoked potentials (MEPs) elicited by TMS and electrical stimulation were measured in the FDI muscle before and after each protocol in humans with and without (controls) chronic cervical SCI. We found in control participants that MEPs elicited by TMS and electrical stimulation increased to a similar extent after both PCMS protocols for ∼30 min. Whereas, in humans with SCI, MEPs elicited by TMS...Continue Reading

Citations

Aug 29, 2019·Journal of Neurophysiology·Roberta Vastano, Monica A Perez
May 27, 2020·Neurorehabilitation and Neural Repair·Supriyo ChoudhuryStuart N Baker
Jun 28, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lasse Christiansen, Monica A Perez
Sep 29, 2020·Experimental Neurology·Lasse ChristiansenMonica A Perez
Nov 19, 2020·Journal of Neurophysiology·Marco Bonizzato
Oct 23, 2020·Journal of Neuroengineering and Rehabilitation·Louis N AwadMark G Bowden
Oct 16, 2020·Journal of Neural Engineering·Jordan A BorrellShawn B Frost
Mar 30, 2021·Current Physical Medicine and Rehabilitation Reports·Hang Jin JoMonica A Perez
May 21, 2021·Advanced Materials·Giorgio ContaJun Chen
May 23, 2021·The Journal of Physiology·Michael A UrbinGeorge F Wittenberg
Nov 16, 2021·The Journal of Spinal Cord Medicine·Hang Jin JoMonica A Perez

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