Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling

The Journal of Pharmacology and Experimental Therapeutics
Samarjit DasDipak K Das

Abstract

Resveratrol (3,4',5-trihydroxy-trans-stilbene), a naturally occurring polyphenolic compound found abundantly in grape skins and red wines, has been found to pharmacologically precondition the heart against ischemia reperfusion injury through the potentiation of a survival signal involving cAMP response element-binding protein-dependent phosphatidylinositol 3-kinase-Akt-BclII pathway. The present study was designed to determine whether, similar to ischemic preconditioning, resveratrol uses mitogen-activated protein kinases (MAPKs) as upstream signaling targets. The isolated rat hearts were preperfused for 15 min with Krebs-Henseleit bicarbonate buffer in the absence (control) or presence of extracellular signal-regulated kinase (ERK) 1/2 inhibitor 2'-amino-3'-methoxyflavone (PD98059), p38 MAPK inhibitor 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole (SB-202190), mitogen- and stress-activated protein kinase 1 (MSK-1) inhibitor N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89), protein kinase A inhibitor (9S,10S,12R)-2,3,9,10,11,12-hexahydro-10hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3fg: 3',2',1'-kl]-pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester (KT5720), resveratrol only, resve...Continue Reading

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Citations

Mar 23, 2012·Journal of Bioenergetics and Biomembranes·Belma TuranGuy Vassort
Feb 27, 2009·Nutrition Research Reviews·Anna TrzeciakiewiczMarie-Noëlle Horcajada
May 13, 2009·Antioxidants & Redox Signaling·Shazib Pervaiz, Andrea Lisa Holme
Mar 11, 2010·Antioxidants & Redox Signaling·Lisa G WoodManohar L Garg
Aug 24, 2010·Antioxidants & Redox Signaling·Goran PetrovskiDipak K Das
Jan 1, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Toru KonoMasahiro Yamamoto
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Anindita DasRakesh C Kukreja
Sep 17, 2008·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Eva Valouskova, Martin Modriansky
Apr 17, 2009·Canadian Journal of Physiology and Pharmacology·Suresh Varma Penumathsa, Nilanjana Maulik
Nov 16, 2010·Canadian Journal of Physiology and Pharmacology·Subhendu MukherjeeDipak K Das
Mar 20, 2010·Heart Failure Reviews·Dipak K DasDiptarka Ray
Mar 15, 2011·Heart Failure Reviews·Dipak K DasDiptarka Ray
Aug 13, 2008·Medical Hypotheses·Lan TanHua-Shi Guan
Nov 30, 2007·Free Radical Biology & Medicine·Samarjit DasDipak K Das
Dec 17, 2008·Molecular Nutrition & Food Research·Mehdi ShakibaeiBharat B Aggarwal
Nov 28, 2006·Journal of Cellular and Molecular Medicine·Karel BezstarostiDipak K Das
Oct 6, 2009·Journal of Cellular and Molecular Medicine·Istvan LekliDipak K Das
Sep 27, 2006·Trends in Neurosciences·Mark P Mattson, Aiwu Cheng
Sep 14, 2011·European Journal of Pharmacology·Gil-Saeng JeongYoun-Chul Kim
Jan 16, 2007·Journal of Molecular and Cellular Cardiology·Buddhadeb Dawn
Aug 22, 2006·Biochemical Pharmacology·Irfan RahmanPaul A Kirkham
Sep 28, 2016·Life Sciences·Stephanie Carvalho BorgesNilza Cristina Buttow
Dec 31, 2010·Dose-response : a Publication of International Hormesis Society·Subhendu MukherjeeDipak K Das
Apr 19, 2008·IUBMB Life·Luciano Pirola, Sara Fröjdö
Oct 20, 2018·Biomolecules & Therapeutics·John M Pezzuto
Dec 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Samarjit DasDipak K Das
Mar 29, 2019·Archives of Pharmacal Research·Dong-Hoon Hyun
Feb 27, 2007·The Journal of Pharmacology and Experimental Therapeutics·Alkje MoritzHeinz H Pertz

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