PMID: 7513807May 1, 1994Paper

Potentiation of bleomycin by the aminothiol WR-1065 in assays for chromosomal damage in G0 human lymphocytes

Mutation Research
G R HoffmannL G Littlefield

Abstract

The aminothiol radioprotector WR-1065 potentiates the induction of chromosome aberrations and micronuclei by the chemotherapy drug bleomycin in G(0) human lymphocytes. Potentiation by 5 mM WR-1065 was observed at bleomycin concentrations from 0.1 to 100 micrograms/ml in a 2-h treatment. The frequencies of micronuclei induced by bleomycin in the presence of WR-1065 reached that of 500-fold higher concentrations of bleomycin alone. The potential therapeutic implications of these findings are discussed.

References

Jan 1, 1978·Mutation Research·B K Vig, R Lewis
Jan 1, 1992·Environmental and Molecular Mutagenesis·A D KligermanG L Erexson
Mar 1, 1991·Mutation Research·L F Povirk, M J Austin
Jan 1, 1991·Archives of Toxicology·J HayG Laurent
Aug 1, 1986·International Journal of Radiation Oncology, Biology, Physics·B Nagy, D J Grdina
Jan 1, 1988·Pharmacology & Therapeutics·D GloverJ H Glick
Feb 1, 1985·Mutation Research·M Fenech, A A Morley
Jan 1, 1993·Environmental and Molecular Mutagenesis·G R HoffmannL G Littlefield
Jan 1, 1993·Environmental and Molecular Mutagenesis·G R HoffmannL G Littlefield

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Citations

Sep 5, 1998·Mutation Research·F Palitti
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G R HoffmannP D McMaster
Feb 23, 2013·Archives of Environmental & Occupational Health·Anabela MiraDaniel M López-Larraza
Sep 15, 2010·Environmental and Molecular Mutagenesis·George R HoffmannJason P Tartaglione
Dec 10, 1995·Molecular & General Genetics : MGG·G R HoffmannL G Littlefield

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