Potentiation of carbon tetrachloride hepatotoxicity by piperine

Drug and Chemical Toxicology
P PiyachaturawatC Toskulkao

Abstract

The effect of piperine on CCl4-induced hepatotoxicity was investigated in rats. Piperine pretreatment potentiated the hepatotoxicity of CCl4 in a dose-dependent manner. The maximum potentiation occurred when piperine at a dose of 100 mg/kg BW was intragastrically administered 4 h prior to an intraperitoneal injection of CCl4, at which time the activities of plasma glutamic pyruvic transaminase (PGPT) and plasma glutamic oxaloacetic transaminase (PGOT) were elevated by 70-80%. Concurrent with the rise in PGPT and PGOT activities, the accumulation of hepatic triglyceride increased whereas the plasma level of triglyceride decreased. Piperine pretreatment also potentiated CCl4-induced lipid peroxidation in the liver. The extent of potentiation correlated well with the rise of hepatic enzyme activity in plasma. In the in vitro system in which the tissue was preincubated with piperine and CCl4 was added into the incubation medium, piperine also exhibited a concentration dependent potentiation on CCl4-induced lipid peroxidation and on the activity of NADPH-cytochrome c-reductase. The results indicated that piperine potentiated CCl4-induced hepatotoxicity by interacting with liver cells and increased the activity of NADPH-cytochrome c ...Continue Reading

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Citations

Nov 8, 2007·Critical Reviews in Food Science and Nutrition·K Srinivasan
Apr 30, 2013·Phytotherapy Research : PTR·Murlidhar Meghwal, T K Goswami
Nov 18, 2000·Journal of Biochemical and Molecular Toxicology·F M RauscherJ B Watkins
Nov 9, 2017·International Journal of Molecular Sciences·Christopher Trent Brewer, Taosheng Chen
Nov 11, 2005·Asian Journal of Andrology·S C D'cruz, P P Mathur
Nov 26, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yi LinLei Pan

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