Potentiation of cholecystokinin-induced exocrine secretion by both exogenous and endogenous insulin in isolated and perfused rat pancreata

The Journal of Clinical Investigation
A SaitoT Kanno

Abstract

Using an isolated perfused rat pancreas preparation, the interrelationship between the endocrine and exocrine portions of the pancreas were studied. Addition of exogenous rat insulin (1-20 mU/ml) to the perfusing solution potentiated the action of cholecystokinin (CCK) (1 mU/ml) to increase both pancreatic juice flow and the release of the enzyme, amylase. Raising the glucose concentration in the perfusing solution from 2.5 to 17.5 mM both increased endogenous insulin release and potentiated the CCK-induced exocrine secretory response. Two lines of evidence indicated that this effect of glucose on the exocrine pancreas was mediated by endogenous insulin release. First, the addition of comparable amounts of xylose or galactose to the perfusion medium neither released insulin nor potentiated the CCK-induced response. Second, epinephrine blocked the effect of high glucose on both insulin release and potentiation of CCK action. Epinephrine alone did not affect the action of CCK. The magnitude of the exocrine response induced by high glucose was comparable to that of 2.5 mU/ml exogenous insulin. It seems possible that pancreatic acinar cells can be exposed to insulin levels of this magnitude in situ.

References

Sep 29, 1978·Biochemical and Biophysical Research Communications·M KorcI D Goldfine
Aug 30, 1969·Lancet·J R Henderson
Apr 1, 1967·The Journal of Clinical Investigation·R H UngerA M Eisentraut
Sep 1, 1968·Endocrinology·D L CurryG M Grodsky
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·M F Kramer, H T Tan
Mar 31, 1959·Acta Physiologica Scandinavica·A C IVY, H M JANECEK

❮ Previous
Next ❯

Citations

Nov 1, 1993·The Histochemical Journal·I S Park, M Bendayan
Jan 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·P M BrannonN Kretchmer
Mar 1, 1987·The British Journal of Nutrition·J Mizoguchi, T Imamichi
Aug 29, 1981·British Medical Journal
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·C IwabeN Hayashi
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·W Y Chey, T Chang
Feb 1, 1982·The Journal of Clinical Investigation·E R TrimbleA E Renold
Jul 1, 1982·The Journal of Clinical Investigation·M Otsuki, J A Williams
May 18, 2000·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T TakácsJ Lonovics
Sep 25, 2007·Regulatory Peptides·V GigouxM Dufresne
May 1, 1989·The Journal of Surgical Research·R H BellP J McCullough
Nov 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·A K Foulis, B M Frier
Nov 20, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·T TakácsJ Lonovics
Feb 1, 1987·Journal of Dental Research·L C Anderson
Apr 11, 2013·Laboratory animal research·Zheng-Er JiangYun-Lyul Lee
May 12, 2019·Reviews in Endocrine & Metabolic Disorders·Laure Alexandre-HeymannEtienne Larger
Apr 17, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Savio G BarretoGino T P Saccone
Jun 1, 1983·The Proceedings of the Nutrition Society·E L Blair
May 1, 1993·Metabolism: Clinical and Experimental·J von SchönfeldH Goebell
Mar 1, 1995·Gastroenterology·M E MailliardG E Mann
Oct 1, 1989·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·C Alvarez, M A López
Oct 1, 1989·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·D BaniG Biliotti
Oct 1, 1994·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·J von SchönfeldM K Müller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.