Potentiation of ciprofloxacin action against Gram-negative bacterial biofilms by a nitroxide

Pathogens and Disease
Fany ReffuveilleRobert E W Hancock

Abstract

We previously showed that soluble nitroxides (nitric oxide analogues) mimicked the well-established ability of nitric oxide to cause biofilm dispersal and further showed that these compounds could prevent biofilm formation. Here, we investigated the effect of the nitroxide carboxy-TEMPO in combination with sub μg/ml concentrations of ciprofloxacin on pre-formed flow cell biofilms formed by Gram-negative bacteria. Combination therapy led to substantial eradication of existing biofilms formed by Pseudomonas aeruginosa PA14 (99.3%) and Escherichia coli O157 (93%).

References

Oct 20, 2006·Journal of Bacteriology·Nicolas BarraudJeremy S Webb
Oct 7, 2008·Chemical Research in Toxicology·Magdalena A LamMichael J Davies
Nov 15, 2008·Nature Reviews. Microbiology·Margo Chase-ToppingMark Woolhouse
Jun 15, 2011·Trends in Microbiology·Elena B M BreidensteinRobert E W Hancock
Nov 29, 2011·Nature Reviews. Microbiology·Diane McDougaldStaffan Kjelleberg
Jul 24, 2013·Antimicrobial Agents and Chemotherapy·César de la Fuente-NúñezRobert E W Hancock
Jul 25, 2013·Current Opinion in Microbiology·César de la Fuente-NúñezRobert E W Hancock

❮ Previous
Next ❯

Citations

Sep 26, 2017·Nature Reviews. Microbiology·Hyun KooLuanne Hall-Stoodley
Nov 21, 2019·Medicinal Research Reviews·Miao Yu, Song Lin Chua
Oct 23, 2019·Antimicrobial Agents and Chemotherapy·Anthony D VerderosaMakrina Totsika
Jun 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anthony D VerderosaKathryn E Fairfull-Smith
Jun 14, 2019·MedChemComm·Anthony D VerderosaKathryn E Fairfull-Smith
Dec 19, 2019·Frontiers in Chemistry·Anthony D VerderosaKathryn E Fairfull-Smith
Nov 21, 2020·International Journal of Molecular Sciences·Minh Tam Tran ThiBernd H A Rehm
Nov 13, 2020·Drug Discovery Today·Laurent R ChiarelliMaria Rosalia Pasca
Apr 16, 2021·Expert Review of Anti-infective Therapy·Jose L Del Pozo
Jul 13, 2021·Frontiers in Microbiology·Alaka SahooSujogya Kumar Panda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.