Abstract
The present experiments were undertaken in order to examine mechanisms of action for reported interactions between the beta-blocker (-)-pindolol and serotonergic agents. It was found that pretreatment with (-)-pindolol (2 mg kg-1 s.c.) potentiated the stereotyped forward locomotion induced by the 5-HT2A/C receptor agonist DOI (0.125-1.0 mg kg-1 s.c.) in rats observed in an open-field arena. This (-)-pindolol/DOI-induced stereotyped forward locomotion was fully antagonized by the 5-HT2A/C receptor antagonist ritanserin (2 mg kg-1 s.c.), suggesting that (-)-pindolol enhances serotonin release, resulting i.a. in postsynaptic 5-HT2A/C receptor activation. This effect by (-)-pindolol is in all probability indirect since this compound lacks affinity for 5-HT2A/C receptors, and could be explained by reported antagonism of inhibitory serotonergic somato-dendritic 5-HT1A autoreceptors, although other possibilities related to 5-HT1B receptors or beta-adrenoceptors can not be excluded at this time. Furthermore, (-)-pindolol treatment also enhanced 5-HTP-induced (12.5-100 mg kg-1 i.p.) effects on spontaneous motor activity. These effects, however, were of smaller magnitude, and less consistent than those seen in combination with DOI.
References
May 1, 1978·Journal of Medicinal Chemistry·U H LindbergS O Ogren
Apr 1, 1991·Journal of Pharmacological Methods·E EricsonS Ahlenius
Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·F D YoccaA S Eison
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·N A DarmaniR A Glennon
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·R A Glennon
May 7, 1990·Brain Research·J A StamfordJ Millar
Nov 1, 1985·Neuropharmacology·S Hjorth, A Carlsson
Nov 26, 1985·European Journal of Pharmacology·D HoyerH O Kalkman
Jun 1, 1971·The Journal of Pharmacy and Pharmacology·K FuxeJ Engel
Oct 27, 1972·Brain Research·L K NgI J Kopin
Aug 1, 1971·Physiology & Behavior·D Winer
Aug 19, 1967·Nature·G BartholiniA Pletscher
Dec 1, 1984·Neuropharmacology·A R Green
Jun 15, 1984·European Journal of Pharmacology·M ShannonM Titeler
Jul 1, 1995·Trends in Pharmacological Sciences·J J Lucas, R Hen
Jan 16, 1995·The Journal of Comparative Neurology·D E WrightL Jennes
Feb 1, 1995·Pharmacology & Toxicology·S Ahlenius, P Salmi
Aug 22, 1994·European Journal of Pharmacology·A AlbinssonG Andersson
Jan 11, 1996·European Journal of Pharmacology·V HillegaartS Ahlenius
Citations
Oct 9, 2007·Psychopharmacology·Tomás PálenícekJirí Horácek
Aug 28, 1999·Neuropharmacology·M J Millan, A Gobert
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·T KoskinenJ Sirviö
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Phillip J SeibellDennis E Rhoads
Jun 29, 2002·Nuclear Medicine and Biology·Yolanda Zea-PonceMarc Laruelle
Dec 2, 2000·Journal of Medicinal Chemistry·J B BlairD E Nichols