PMID: 7335107Dec 1, 1981Paper

Potentiation of genotoxicity by concurrent application of compounds found in betel quid: arecoline, eugenol, quercetin, chlorogenic acid and Mn2+

Mutation Research
H F StichP P Lam

Abstract

5 components of the betel quid were examined for their clastogenic activities individually and in various combinations. They included the alkaloid, arecoline, from the betel nut (Areca catechu L.), eugenol, from the betel vine (Piper belle L.), chlorogenic acid, from tobacco leaves (Nicotiana tabacum), quercetin, from fennel seeds (Foeniculus vulgare Mill.) and the ubiquitous transition metal Mn2+. The clastogenic effects of the concurrent applications of arecoline plus eugenol, arecoline plus quercetin and arecoline plus chlorogenic acid were greater than the sum of the action of each individual component. Similarly, the combinations of arecoline, chlorogenic acid and Mn2+ induced frequencies of chromosome aberrations which exceeded the sum of the clastogenic activities of individually applied compounds or the sum of the clastogenic activities of 2 jointly applied compounds (arecoline plus Mn2+, or chlorogenic acid plus Mn2+). The clastogenic activity was estimated as the frequency of metaphase plates with at least 1 chromatid break or chromatid exchange, or the average number of chromatid breaks and exchanges per Chinese hamster ovary (CHO) cell. A potentiating (enhancing) action was also evident when 2 clastogens were used a...Continue Reading

References

Jan 1, 1979·Lancet·J AshbyE Boyland
Aug 14, 1978·Biochemical and Biophysical Research Communications·D YoshidaT Matsuzaki
Jan 1, 1979·Mutation Research·J B Guttenplan
Dec 15, 1979·International Journal of Cancer. Journal International Du Cancer·K J RanadiveS V Gothoskar
Jul 1, 1974·Mutation Research·J A Heddle
Jun 1, 1980·Mutation Research·H F StichA B Acton
Jul 1, 1981·Cancer Letters·H F StichW D Powrie
Mar 1, 1980·Biochemical Pharmacology·R F WhitingH F Stich

❮ Previous
Next ❯

Citations

Jan 1, 1992·Teratogenesis, Carcinogenesis, and Mutagenesis·A AllavenaG Brambilla
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·B J DaveS G Adhvaryu
Jun 1, 1985·Mutation Research·H F Stich, M P Rosin
Feb 1, 1989·Mutation Research·W W Piegorsch, B H Margolin
Apr 1, 1984·Mutation Research·S K Abraham, P C Kesavan
Dec 1, 1983·Mutation Research·G B Panigrahi, A R Rao
Feb 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A B SarmaA Mukherjee
Jul 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Singh, A R Rao
Jun 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K PolasaI S Shenolikar
Oct 1, 1989·Journal of Ethnopharmacology·S SenA Sharma
Jan 1, 1988·Journal of Toxicology and Environmental Health·K C DonnellyS Safe
Apr 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C W van WykA F Grobler-Rabie
Dec 18, 2013·BMC Cancer·Ibtehaj Al-SharifAbdelilah Aboussekhra
Jan 18, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·David KirklandRaffaella Corvi
Jan 1, 1983·Archives of Oral Biology·D M Parisis, E T Pritchard
Apr 1, 1984·Journal of Oral Pathology·P ReichartU Mohr
Dec 21, 2017·Nutrients·Daniel Pereira BezerraDamião Pergentino de Sousa
Apr 24, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jianhong ZhouJie Zhang
Nov 15, 1982·International Journal of Cancer. Journal International Du Cancer·H F StichB B Parida
May 1, 1994·Journal of Dental Research·J H JengM Y Kuo
Dec 3, 2004·The Journal of Biological Chemistry·Rita GhoshAddanki P Kumar
May 15, 1984·International Journal of Cancer. Journal International Du Cancer·A R Rao
Oct 25, 2020·Archives of Toxicology·Nuno G OliveiraRicardo Jorge Dinis-Oliveira
Dec 4, 2004·Mutation Research·Katsuhisa SakanoShosuke Kawanishi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.