PMID: 8614271Jan 1, 1996Paper

Potentiation of glucagon-like peptide 1 insulinotropic action by succinic acid dimethyl ester

Life Sciences
V Leclercq-Meyer, W J Malaisse

Abstract

The glucagon-like peptide 1 (7-36) amide (GLP-1, 1.0 nM) was administered to isolated rat pancreases perfused either in the absence of exogenous nutrient or presence of 10 mM succinic acid dimethyl ester (SAD). In the absence of any exogenous nutrient, GLP-1 failed to affect either insulin or glucagon release. The administration of SAD caused a biphasic stimulation of insulin output and inhibited glucagon secretion. In the presence of SAD, GLP-1 still failed to affect glucagon release, but markedly enhanced insulin secretion. These findings indicate that GLP-1 is not truly a glucose-dependent, but rather nutrient-dependent insulin secretagogue. They also suggest that non-glucidic nutrients, such as SAD, could be used to optimalize the B-cell secretory response to GLP-1 in non-insulin-dependent diabetes mellitus.

References

Mar 1, 1992·The American Review of Respiratory Disease·N F VoelkelR C Murphy
Mar 1, 1989·Diabetes·G C WeirJ F Habener
Aug 1, 1995·Biochemical and Molecular Medicine·T M ZhangW J Malaisse
Jul 1, 1992·Trends in Endocrinology and Metabolism : TEM·H C Fehmann, J F Habener
Jun 7, 2011·The American Journal of Cardiology·Vincent E FriedewaldWilliam C Roberts

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Citations

Apr 23, 2004·Trends in Pharmacological Sciences·Arash NourparvarRiccardo Perfetti
Apr 23, 1997·European Journal of Pharmacology·J A García-MartínezW J Malaisse
May 7, 1998·European Journal of Pharmacology·L LadrièreW J Malaisse
Aug 14, 1998·General Pharmacology·L LadrièreW J Malaisse
Jan 19, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G G Holz, G Holz

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