Potentiation of hypoxic ventilatory response by hyperoxia in the conscious rat: putative role of nitric oxide

Journal of Applied Physiology
D Gozal

Abstract

In humans, the hypoxic ventilatory response (HVR) is augmented when preceded by a short hyperoxic exposure (Y. Honda, H. Tani, A. Masuda, T. Kobayashi, T. Nishino, H. Kimura, S. Masuyama, and T. Kuriyama. J. Appl. Physiol. 81: 1627-1632, 1996). To examine whether neuronal nitric oxide synthase (nNOS) is involved in such hyperoxia-induced HVR potentiation, 17 male Sprague-Dawley adult rats underwent hypoxic challenges (10% O2-5% CO2-balance N2) preceded either by 10 min of room air (-O2) or of 100% O2 (+O2). At least 48 h later, similar challenges were performed after the animals received the selective nNOS inhibitor 7-nitroindazole (25 mg/kg ip). In -O2 runs, minute ventilation (VE) increased from 121.3 +/- 20.5 (SD) ml/min in room air to 191.7 +/- 23.8 ml/min in hypoxia (P < 0.01). After +O2, VE increased from 114.1 +/- 19.8 ml/min in room air to 218.4 +/- 47. 0 ml/min in hypoxia (+O2 vs. -O2: P < 0.005, ANOVA). After 7-nitroindazole administration, HVR was not affected in the -O2 treatment group with VE increasing from 113.7 +/- 17.8 ml/min in room air to 185.8 +/- 35.0 ml/min in hypoxia (P < 0.01). However, HVR potentiation in +O2-exposed animals was abolished (111.8 +/- 18. 0 ml/min in room air to 184.1 +/- 35.6 ml/min in h...Continue Reading

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Citations

Aug 12, 2003·Journal of Applied Physiology·Jay B DeanRichard A Henderson
Sep 17, 2004·Experimental Lung Research·Harald GroebenClarke G Tankersley
Jun 26, 2010·Journal of Applied Physiology·Ryan W BavisDonna A Rampersad
Oct 23, 2002·Journal of Applied Physiology·Ryan W Bavis, Gordon S Mitchell
Jan 13, 2004·Journal of Applied Physiology·Jay B DeanRobert W Putnam
May 24, 2007·PLoS Medicine·Paul M MaceyRonald M Harper
Dec 31, 2002·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Barbara E TaylorJohn E Remmers
Jul 20, 1999·Journal of Applied Physiology·H Gautier, C Murariu
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael B HarrisJohn E Remmers
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·H NakanoG A Farkas
Apr 12, 2001·Journal of Applied Physiology·D K MulkeyJ B Dean
Apr 22, 2003·Journal of Applied Physiology·Daniel K MulkeyJay B Dean
Sep 1, 2009·Autonomic Neuroscience : Basic & Clinical·Erica M GranjeiroBenedito H Machado
Sep 13, 2008·Respiratory Physiology & Neurobiology·Stephen R ReevesDavid Gozal

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