Potentiation of in vitro concentric work in mouse fast muscle

Journal of Applied Physiology
R W GrangeM E Houston

Abstract

Phosphorylation of myosin regulatory light chain (R-LC) is associated with potentiated work and power during twitch afterloaded contractions in mouse extensor digitorum longus muscle [R. W. Grange, C. R. Cory, R. Vandenboom, and M. E. Houston. Am. J. Physiol. 269 (Cell Physiol. 38): C713-C724, 1995]. We now describe the association between R-LC phosphorylation and potentiated concentric work when the extensor digitorum longus muscle is rhythmically shortened and lengthened to simulate contractions in vivo. Work output (at 25 degrees C) was characterized at sine frequencies of 3, 5, 7, 10, and 15 Hz at excursions of 0.6, 1.2, and 1.6 mm (approximately 5, 9, and 13% optimal muscle length) at a low level of R-LC phosphorylation. Muscles stimulated during the sine function with a single twitch at specific times before or after the longest muscle length yielded maximal concentric work near the longest muscle length at a sine frequency of 7 Hz (e.g., excursion approximately 9% optimal muscle length = 1.6 J/kg). Power increased linearly between sine frequencies of 3 and 15 Hz at all excursions (maximum approximately 29 W). After a 5-Hz 20-s conditioning stimulus and coincident with a 3.7-fold increase in R-LC phosphate content (e.g., ...Continue Reading

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Citations

Jan 22, 2002·Exercise and Sport Sciences Reviews·S Jayne Garland, E Roderich Gossen
Jun 17, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·David G Behm
Feb 6, 2009·International Journal of Sports Physiology and Performance·Michael H StoneG Gregory Haff
Apr 14, 2010·Journal of Strength and Conditioning Research·Elizabeth E LinderJohn R Solomon
Jun 15, 2010·Journal of Strength and Conditioning Research·Lawrence W JudgeMike Judge
Jan 7, 2014·Medicine and Science in Sports and Exercise·Paulo GagoMaria M Ekblom
Oct 29, 2013·Journal of Muscle Research and Cell Motility·Rene VandenboomJames T Stull
Feb 29, 2000·Medicine and Science in Sports and Exercise·T HamadaJ D Macdougall
Apr 19, 2011·Pflügers Archiv : European journal of physiology·Jason XeniRene Vandenboom
Jun 10, 2020·Biology Letters·Kari R Taylor-BurtAndrew A Biewener
Apr 7, 2009·Muscle & Nerve·Damien M CallahanJane A Kent-Braun
Jan 15, 2010·Journal of Strength and Conditioning Research·Ryan M RubenG Gregory Haff
Jan 25, 2011·The Journal of Biological Chemistry·Kristine E Kamm, James T Stull
Aug 3, 2018·Journal of Sports Sciences·Francisco Cuenca-FernándezRaúl Arellano
Mar 1, 2002·Muscle & Nerve·Stuart A Binder-MacleodJun Ding
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Nov 30, 2016·Pflügers Archiv : European journal of physiology·Joshua BowslaughRene Vandenboom
Jun 19, 2018·Journal of Strength and Conditioning Research·Francisco Cuenca-FernándezRaúl Arellano
Oct 27, 2020·Journal of Strength and Conditioning Research·Francisco Cuenca-FernándezRaúl Arellano
Nov 11, 2011·The Journal of Experimental Biology·Daniel CateriniRene Vandenboom
Feb 3, 2011·Archives of Biochemistry and Biophysics·James T StullRene Vandenboom
Mar 8, 2011·Annals of Physical and Rehabilitation Medicine·S Boyas, A Guével

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