PMID: 6991327May 1, 1980Paper

Potentiation of insulin secretion to nonglucose stimuli in normal man by tolbutamide

Diabetes
M A PfeiferD Porte

Abstract

To determine how sulfonylureas affect beta cell function, insulin release in response to isoproterenol and arginine was assessed in 32 normal subjects before and during a tolbutamide infusion. When the plasma glucose was allowed to decrease during tolbutamide, the acute insulin response (AIR) to isoproterenol was not changed (delta AIR = 4 +/- 8 MicroU/ml, mean +/- SEM, n = 8,p = NS) and was enhanced slightly for arginine (delta AIR = +61 +/- 26 microU/ml, n = 6, p less than 0.05). When plasma glucose levels were maintained by means of a concomitant variable glucose infusion during tolbutamide, the insulin responses to both isoproterenol and arginine were enhanced (isoproterenol: delta AIR = +55 +/- 15 microU/ml, n = 6, p less than 0.001; arginine: delta AIR = +137 +/- 34 microU/ml, n = 8, p less than 0.001). Regression analysis demonstrated a linear relationship between change in the prestimulus glucose level and the change in the AIR to isoproterenol during tolbutamide (r = 0.66, n = 14, p less than 0.02). Since the slope of his relationship is not significantly different from a similar relationship in the absence of tolbutamide, the potentiating effect of tolbutamide is an amplification of an established physiologic relation...Continue Reading

Citations

Jan 1, 1982·European Journal of Clinical Pharmacology·G SartorE Wåhlin-Boll
Oct 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C R Sirtori, C Pasik
Sep 1, 2011·Diabetes Research and Clinical Practice·Jean-Claude Henquin
Jan 1, 1991·Diabetes Research and Clinical Practice·D R MatthewsI Stratton
Mar 1, 1981·The American Journal of Medicine·M A PfeiferD Porte
Jan 17, 1983·The American Journal of Medicine·R A DeFronzoV Koivisto
Dec 1, 1983·Australian and New Zealand Journal of Medicine·A H BarnettJ Smith
May 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·C Y JengG M Reaven
Feb 1, 1984·Annals of the Rheumatic Diseases·R GaleP J Roberts-Thomson
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Simon M ChalkleyEdward W Kraegen
Apr 28, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·D C WhitelawM Nattrass
Oct 27, 2005·American Journal of Physiology. Endocrinology and Metabolism·Nobuyoshi IshiyamaJean-Claude Henquin
Nov 1, 1989·The Journal of International Medical Research·J P BelonC Jacquot
Nov 30, 2006·Diabetes·Jean-Claude HenquinMyriam Nenquin
May 12, 1998·The American Journal of Physiology·A Rostami-HodjeganG T Tucker
Aug 20, 1990·The American Journal of Medicine·N M O'MearaK S Polonsky

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