Potentiation of interferon-mediated inhibition of Chlamydia infection by interleukin-1 in human macrophage cultures.

Infection and Immunity
Joseph M Carlin, J B Weller

Abstract

One mechanism by which interferons (IFNs) can inhibit chlamydial infection is by the induction of the enzyme indoleamine 2,3-dioxygenase (IDO), which restricts the availability of tryptophan, which is required for chlamydial growth. Other immunomodulating agents, including interleukin-1 (IL-1), can interact synergistically with IFNs, resulting in increased IDO activity in macrophages. The objectives of this study were to establish that IL-1 can enhance IFN-mediated inhibition of chlamydial growth by increasing the amount of IDO activity induced by IFNs and to identify immunomodulatory agents in culture supernatants from chlamydia-infected macrophages that interact synergistically with IFNs in restricting chlamydial growth. Monocyte-derived macrophages were treated with IL-1 combined with gamma IFN (IFN-gamma) or IFN-beta. The ability of treated cells to support the growth of Chlamydia psittaci was directly related to the amount of IDO activity induced; as IDO activity increased, so did inhibition of chlamydial growth. Furthermore, concentrations of IFNs were identified at which little IDO activity was induced and chlamydial growth was permitted yet which in the presence of IL-1 resulted in increased IDO activity and restriction...Continue Reading

References

Mar 1, 1978·Clinical and Experimental Dermatology·R L SpielvogelR W Goltz
Mar 1, 1992·Infection and Immunity·D M MageeD M Williams
Jan 1, 1989·Journal of Leukocyte Biology·J M CarlinG I Byrne
Sep 1, 1989·Infection and Immunity·C D RothermelT Francus
May 1, 1985·Infection and Immunity·Y Shemer, I Sarov
Feb 1, 1986·The Journal of Clinical Investigation·J M DayerC A Dinarello
Dec 1, 1983·The Journal of Experimental Medicine·J Turco, H H Winkler
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W L BeattyR P Morrison
Jan 1, 1993·Infection and Immunity·X Jiang, C L Baldwin

❮ Previous
Next ❯

Citations

May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antonio Gigliotti RothfuchsMartín E Rottenberg
Jan 24, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Ursula HainzAndreas Heitger
Sep 7, 2013·Scandinavian Journal of Immunology·Y Furuya, A Müllbacher
May 11, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A R CurrierJ M Carlin
Mar 25, 2004·Infection and Immunity·Richard J HoganPeter Timms
Aug 20, 2005·Nature Reviews. Immunology·Thomas DeckerSilvia Stockinger
Jan 24, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kari Ann ShireyJoseph M Carlin
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toni DarvilleDavid M Ojcius
Jul 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B HuJ M Carlin
Sep 19, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexey Popov, Joachim L Schultze
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M E RottenbergH Wigzell
Mar 14, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tanvi AgrawalAruna Mittal
Feb 21, 2009·Journal of Periodontology·Kanokwan NisapakultornOsamu Takikawa
Jul 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B D Hissong, J M Carlin
May 25, 1999·Infection and Immunity·H MatsushimaT Nakazawa
Feb 20, 1999·Infection and Immunity·S AirenneA Laurila
Jun 30, 2019·Frontiers in Cellular and Infection Microbiology·Dezső P VirokKatalin Burián
Jan 19, 2018·Journal of Leukocyte Biology·Claudia J StocksRonan Kapetanovic
Oct 1, 1996·Clinical Microbiology Reviews·L H HoganS M Levitz
Jun 8, 2021·Frontiers in Immunology·Wenjing XiangZhou Zhou
Dec 23, 2008·Enfermedades infecciosas y microbiología clínica·Enrique VillegasJosé Gutiérrez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
A R CurrierJoseph M Carlin
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
B D Hissong, Joseph M Carlin
© 2021 Meta ULC. All rights reserved