Potentiation of invasive capacity of rat ascites hepatoma cells by transforming growth factor-beta

Japanese Journal of Cancer Research : Gann
M MukaiH Akedo

Abstract

The in vitro invasive capacity of poorly invasive cells (W1), which were cloned from rat ascites hepatoma cells (AH 130), was potentiated dose- and time-dependently by pretreating the cells with transforming growth factor-beta (TGF-beta). This potentiation of invasive capacity was completely abolished by anti-TGF-beta antibody. When the treated cells were ip inoculated into rats, the cells extensively invaded the peritoneum, and formed penetrating tumor nodules. The effect of TGF-beta was reversed by subculturing the treated cells without TGF-beta. The potentiation of invasive capacity by TGF-beta might participate in platelet-associated enhancement of tumor cell metastasis.

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Citations

Sep 1, 1989·Japanese Journal of Cancer Research : Gann·H OhigashiH Akedo
Aug 1, 1989·Japanese Journal of Cancer Research : Gann·K ShinkaiH Akedo
Jun 6, 2006·Biochemical and Biophysical Research Communications·M MukaiM Inoue
Feb 13, 2001·Gynecologic Oncology·G C RodriguezM S Stack
Jun 1, 1993·Japanese Journal of Cancer Research : Gann·N UekiK Higashino
Apr 1, 1996·Japanese Journal of Cancer Research : Gann·K ShinkaiI Kitagawa
May 1, 1991·Japanese Journal of Cancer Research : Gann·F ImamuraH Akedo
Mar 1, 1996·International Journal of Cancer. Journal International Du Cancer·F ImamuraH Akedo
Feb 14, 2009·Cancer Science·Miki Tanaka-OkamotoJun Miyoshi
Jul 15, 1990·International Journal of Cancer. Journal International Du Cancer·K Guzik, A Klein
Sep 15, 2012·Experimental and Therapeutic Medicine·Hiroyuki NakamuraJun Miyoshi
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Nov 5, 1997·International Journal of Cancer. Journal International Du Cancer·A TetiT Faraggiana
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Y MaeharaK Sugimachi

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