PMID: 9165293Jan 1, 1997Paper

Potentiation of ischemia-reperfusion liver injury by hyperthyroidism in the rat

Free Radical Biology & Medicine
P TroncosoL A Videla

Abstract

Parameters related to hepatic oxidative stress, cell injury, and liver histology were determined in control rats and in animals treated with 3,3',5-triiodothyronine (T3), after in vitro perfusion under normoxic or ischemia-reperfusion conditions. Thyroid calorigenesis was found concomitantly with higher rates of hepatic O2 consumption and thiobarbituric acid reactive substances (TBARS) formation, glutathione (GSH) depletion, enhanced TBARS/GSH ratio as indicator of oxidative stress, and higher sinusoidal lactate dehydrogenase (LDH) efflux compared to control values, assessed under normoxic conditions. Perfused livers from control animals subjected to ischemia-reperfusion exhibited significant increases in the TBARS/GSH ratio and in the sinusoidal LDH efflux over values obtained under normoxic conditions, concomitantly with the appearance of small foci of necrotic cells in centrilobular and midzonal areas of the liver lobule. These parameters were further modified in the liver of hyperthyroid rats subjected to ischemia-reperfusion, with elevations in the TBARS/GSH ratio and in the sinusoidal LDH efflux largely exceeding the sum of effects elicited by hyperthyroidism or ischemia-reflow alone. In this situation, liver injury was m...Continue Reading

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Jan 1, 1997·Free Radical Biology & Medicine·P TroncosoL A Videla

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Citations

Sep 1, 1994·Free Radical Biology & Medicine·F BiasiG Poli
Aug 4, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·U CilloE F De Palo
Jan 1, 1997·Free Radical Biology & Medicine·P TroncosoL A Videla
Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Paola VendittiSergio Di Meo
Jan 28, 2010·Journal of the Chinese Medical Association : JCMA·Chin-Sung KuoHong-Da Lin
Mar 31, 2007·Archives of Biochemistry and Biophysics·P VendittiS Di Meo
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Virginia FernándezLuis A Videla
Jul 16, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Kyung Mee KimBong Chul Chung
Jan 6, 2001·Redox Report : Communications in Free Radical Research·L A Videla
Mar 24, 2000·Redox Report : Communications in Free Radical Research·X BoisierL A Videla
May 26, 2015·Expert Reviews in Molecular Medicine·Luis A VidelaIván Castillo
Aug 29, 2006·Medical & Biological Engineering & Computing·Fuziansyah BachtarToshiaki Hisada

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