Potentiation of lymphocyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon.

Infection and Immunity
D A WeigentG J Stanton

Abstract

Human lymphocytes were treated with human alpha (IFN-alpha), beta (IFN-beta), or recombinant gamma (IFN-gamma) interferons separately or in combination to determine their ability to enhance natural killing against mouse L cell targets. Our results showed that recombinant IFN-gamma was approximately 50 times more active per unit of antiviral activity than either IFN-alpha or IFN-beta. Moreover, the levels of natural killing by lymphocytes treated with combinations of IFN-alpha and IFN-beta were additive, whereas combinations of recombinant IFN-gamma and IFN-alpha or recombinant IFN-gamma and IFN-beta were synergistic. The development of natural killing in lymphocytes treated with recombinant IFN-gamma did not occur more rapidly but reached higher levels (62%) than that observed with lymphocytes treated with IFN-alpha or IFN-beta (15%). The results suggest the importance of IFN-gamma and mixtures of IFN-gamma with IFN-alpha or IFN-beta in the enhancement of natural killing activity against virus infections and neoplasia.

References

Oct 1, 1979·Infection and Immunity·M P LangfordH M Johnson
Oct 1, 1979·Infection and Immunity·W R FleischmannH M Johnson
Jan 1, 1980·Annals of the New York Academy of Sciences·B PerussiaG Trinchieri
Jul 1, 1981·Journal of the American Academy of Dermatology·M M BryskH S Black

❮ Previous
Next ❯

Citations

Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·H O KleinC Bernhardt
Jul 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M J SekellickP I Marcus
Feb 15, 1986·International Journal of Cancer. Journal International Du Cancer·M J Brunda, R B Wright
Oct 1, 1991·Journal of Medical Virology·R A Levandowski, D W Horohov
Apr 1, 1990·Journal of Interferon Research·J N IJzermansR L Marquet
Jan 1, 1984·European Journal of Immunology·J L VirelizierR Devos
Aug 1, 1992·Journal of Interferon Research·T M SchepersK R McLeish
Oct 15, 1987·International Journal of Cancer. Journal International Du Cancer·N K Damle, L V Doyle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.