Potentiation of natriuretic peptide action by the beta-adrenergic blocker carvedilol in hypertensive rats: a new antihypertensive mechanism

Endocrinology
T YoshimotoH Demura

Abstract

Treatment with a beta-adrenergic blocker (beta-blocker) in hypertension is associated with increased plasma atrial natriuretic peptide (ANP) levels despite a decrease in cardiac overload. The mechanism and pathophysiological significance of the phenomenon remain unclear. To clarify the role of the ANP system in the antihypertensive effects of the beta-blocker, we investigated the effects of carvedilol (30 mg/kg x day, orally, for 4 weeks) on the ANP system in stroke-prone spontaneously hypertensive rats (SHR-SP/Izm). Plasma ANP levels showed a significant increase despite a significant decrease in blood pressure and heart rate in the carvedilol group. Although ANP messenger RNA levels in the heart did not change, messenger RNA levels of the natriuretic peptide-C (NP-C) receptor as a clearance receptor showed a significant decrease in both the aorta and lung in the carvedilol group. NP-C receptor densities were also significantly decreased in the lung in this group. The biological half-life of exogenous ANP in circulating blood was prolonged in the carvedilol group compared with that in the control group. Administration of the ANP receptor antagonist, HS-142-1, resulted in a greater increase in systolic blood pressure in the car...Continue Reading

Citations

Jul 25, 2003·European Journal of Drug Metabolism and Pharmacokinetics·P KotridisC L Papadopoulos
Sep 25, 2003·European Journal of Drug Metabolism and Pharmacokinetics·C L Papadopoulos, B A Kokkas
Sep 26, 2003·Journal of Cardiovascular Pharmacology·Anton H van den MeirackerFrans Boomsma
Sep 13, 2002·Microscopy Research and Technique·Magnus Hansson
Feb 27, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T C ChuD E Potter
Nov 4, 2000·Current Hypertension Reports·B J PearsonJ D Spence
May 9, 2002·European Journal of Drug Metabolism and Pharmacokinetics·B KokkasC L Papadopoulos
Jun 15, 2007·Annals of Medicine·Richard W TroughtonM Gary Nicholls
Aug 3, 2001·Cardiovascular Drug Reviews·J ChengI Kodama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.