Potentiation of pirarubicin activity in multidrug resistant cells by rifampicin

Biological & Pharmaceutical Bulletin
S FurusawaY Takayanagi

Abstract

The effect of the anti-tuberculosis drug rifampicin on pirarubicin activity was investigated in multidrug-resistant cells overexpressing P-glycoprotein. Rifampicin increased the sensitivity of pirarubicin to anthracycline-resistant mouse leukemic P388 cells and significantly enhanced the cytotoxicity and intracellular accumulation of pirarubicin in resistant cells, but had no effect in parent cells. By contrast, two other rifamycins, rifamycin B and SV, had no effect on pirarubicin accumulation in resistant cells. Rifampicin also enhanced pirarubicin-induced apoptosis and G2/M blockade on the cell cycle in resistant cells. These results show that rifampicin enhances the cytotoxic action of pirarubicin in resistant cells, at least partly via the inhibition of cellular pirarubicin efflux.

Citations

Jul 27, 2011·Pharmacogenomics·Fabian Müller, Martin F Fromm
Aug 2, 2001·The Journal of Pharmacy and Pharmacology·S FurusawaS Satoh
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jian Zong, Gary M Pollack
Nov 25, 2003·The Journal of Pharmacology and Experimental Therapeutics·Yvonne Y LauLeslie Z Benet
Oct 13, 2020·Journal of Clinical Pharmacology·Akshanth R PolepallyMohamad Shebley

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