PMID: 4293133Jun 1, 1967Paper

Potentiation of secretin stimulation of the pancreas

The Journal of Physiology
J C BrownT Scratcherd

Abstract

1. In fasted anaesthetized cats which were secreting pancreatic juice at a steady slow rate in response to continuous intravenous infusion of secretin, stimulation of the dorsal vagus trunk increased the rate of secretion, the rate of output of amylase and the concentration of bicarbonate in the juice.2. The increase in rate of secretion and in concentration of bicarbonate was reduced but not abolished by atropine. It was unaffected by adrenergic blocking agents, but abolished by hexamethonium.3. No increase in rate of secretion of secretin-stimulated juice was observed on cervical stimulation of vagus nerves in which the efferent fibres had degenerated after supra-nodose section of the nerves. It is concluded that the increase in secretion rate is mediated by ;atropine-resistant' efferent vagal fibres.4. Pancreozymin, antral extracts and histamine increased the rate of secretion of secretin-stimulated juice. Pancreozymin and antral extracts also increased the rate of amylase output. These effects of pancreozymin and antral extracts were not abolished by atropine or hexamethonium.5. As vagal stimulation pancreozymin, antral extracts and histamine have little or no effect on the resting pancreas of the anaesthetized cat, it is c...Continue Reading

Citations

May 1, 1976·Diabetologia·F A O'ConnorM Shahidullah
Aug 1, 1990·Pflügers Archiv : European journal of physiology·E L Stuenkel, S R Hootman
Jan 1, 1979·Acta Physiologica Scandinavica·J J HolstJ Fahrenkrug
May 1, 1969·Acta Physiologica Scandinavica·F W Henriksen, H Worning
Nov 1, 1969·The American Journal of Digestive Diseases·L I Solberg, F P Brooks
Feb 1, 1975·General and Comparative Endocrinology·G J Dockray
Jul 1, 1974·General and Comparative Endocrinology·G J Dockray
Jan 1, 1988·Annals of the New York Academy of Sciences·J J HolstT Skak-Nielsen
Apr 1, 1972·Gut·A A Harper
Jan 1, 1969·Scandinavian Journal of Gastroenterology·F W Henriksen
Jan 1, 1978·Scandinavian Journal of Gastroenterology·M V Singer, H Sarles
Jan 1, 1981·Scandinavian Journal of Gastroenterology·L HendelH Worning
Jan 1, 1969·Scandinavian Journal of Gastroenterology·K G Wormsley
Jan 1, 1968·Scandinavian Journal of Gastroenterology·F W Henriksen
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·M V Singer
Dec 29, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·J H Henriksen, O B de Muckadell
Apr 12, 1973·Biochimica Et Biophysica Acta·W J ThompsonS A Little
Jan 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·W Y Chey
Oct 1, 1989·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·T RöschM Classen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.