PMID: 11313449Apr 21, 2001Paper

Potentiation of sensory responses in the anterior cingulate cortex following digit amputation in the anaesthetised rat

The Journal of Physiology
Feng Wei, Min Zhuo

Abstract

The anterior cingulate cortex (ACC) is important for processing different types of information, including sensory inputs. In the present study on anaesthetised rats, we recorded in vivo sensory responses of the ACC to peripheral electrical shocks. Peripheral electrical stimulation at high intensities sufficient to activate nociceptive sensory fibres elicited EPSPs within the ACC. Digit amputation caused long-lasting potentiation of ACC responses to peripheral electrical stimulation. Evoked field EPSPs remained enhanced for at least 120 min after the amputation. Because electrical shocks were delivered to the normal hindpaw, it is likely that plastic changes occur centrally in the spinal cord or the supraspinal structures following amputation. We also recorded field EPSPs of the ACC in response to focal cortical stimulation within the ACC. Like the sensory responses, field EPSPs produced by focal cortical stimulation within the ACC were potentiated after digit amputation, suggesting that long-lasting changes occurred locally within the ACC. Local blockade of peripheral activity by QX-314 at the amputated hindpaw 120 min after amputation did not significantly affect sensory responses induced within the ACC. Thus, peripheral ongoi...Continue Reading

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Citations

May 18, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiang-Yao LiMin Zhuo
Oct 13, 2009·Molecular Neurobiology·Giannina DescalziMin Zhuo
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Long-Jun Wu, Min Zhuo
Nov 20, 2003·Trends in Neurosciences·Ru-Rong JiClifford J Woolf
Jun 1, 2010·Nature Neuroscience·Nanna GoldmanMaiken Nedergaard
Oct 21, 2006·Nature Reviews. Neuroscience·Herta FlorTroels Staehelin Jensen
Mar 30, 2010·Cerebral Cortex·Zizhen Zhang, Philippe Séguéla
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Min Zhuo
Jan 31, 2009·Epilepsia·Gabriella PanuccioMassimo Avoli
Jan 14, 2011·Science Translational Medicine·Hansen WangMin Zhuo
Jul 2, 2005·Molecular Pain·Min Zhuo
Jun 8, 2007·Molecular Pain·Min Zhuo
Aug 2, 2011·Molecular Brain·Min ZhuoLong-Jun Wu
Apr 17, 2013·Der Schmerz·M Diers, H Flor
Jun 28, 2011·European Journal of Pharmacology·Bihua BieMohamed Naguib
Mar 11, 2008·Trends in Neurosciences·Min Zhuo
Mar 26, 2016·Frontiers in Neuroscience·Giandomenico D'AlessandroPietro Cortelli
Jan 9, 2007·Brain Research Bulletin·Chia-Ming LeeBai-Chuang Shyu
Apr 16, 2010·Annals of the New York Academy of Sciences·John A FossellaJin Fan
Jan 5, 2005·The Journal of Pain : Official Journal of the American Pain Society·Shanelle W KoMin Zhuo
Nov 9, 2005·The Journal of Pain : Official Journal of the American Pain Society·Kunjumon Ittira VadakkanMin Zhuo
Sep 15, 2012·Neuroscience and Biobehavioral Reviews·Mark EgliScott Edwards
Mar 27, 2015·Neural Plasticity·Lisa DoanJing Wang

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