Potentiation of suckling-induced release of prolactin by inhibition of brain catecholamine synthesis

J L Voogt, L A Carr


The effects of a catecholamine synthesis inhibitor, alpha-methyl-p-tyrosine (alpha-MT), on the accumulation of newly synthesized brain catecholamines and plasma prolactin concentration were studied in lactating rats. [3H]tyrosine was administered to rats 10 minutes before decapitation, and the rate of its incorporation into [3H]dopamine and [3H]norepinephrine was measured in whole brain. Injection of alpha-MT (3.15--12.50 mg/kg) via a carotid cannula increased plasma prolactin levels and decreased the accumulation of newly synthesized brain catecholamines in nonsuckled, lactating rats compared to rats injected with .9% saline solution. Mother rats pretreated with saline solution were suckled for 20 minutes by pups which previously were separated from the mother rats for 5 hours. This treatment resulted in significantly increased plasma prolactin levels compared to nonsuckled controls. In rats pretreated with alpha-MT for 20 minutes, suckling resulted in a further increase in plasma prolactin levels which was significantly greater than the increase caused by suckling or alpha-MT alone. These results suggest that inhibition or catecholamine synthesis had a facilitatory effect on the brain mechanisms responsible for prolactin rele...Continue Reading


Oct 15, 1977·European Journal of Pharmacology·Y TachéR Collu
Mar 1, 1978·Clinical Endocrinology·M L BatrinosG P Piaditis
Jan 1, 1995·Biological Psychiatry·B LozoffE Jimenez
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Mai Thanh TuClaire-Dominique Walker
Jan 1, 1978·Endocrine Research Communications·B L BromleyE Zimmerman

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