Potentiation of sufentanil by clonidine in PCEA with or without basal infusion

European Journal of Anaesthesiology
M P VercauterenH A Adriaensen

Abstract

Sufentanil or a sufentanil-clonidine combination was evaluated to determine whether the basal rate in patient-controlled epidural analgesia (PCEA) might affect the daily consumption, quality of analgesia or incidence of side effects. Following Caesarean section delivery, 60 patients were randomly assigned to receive one of the four following PCA regimens (15 patients per group) for the relief of post-operative pain by the epidural route: sufentanil 2 micrograms mL-1 in 0.9% NaCl, demand dose 5 micrograms i.e. 2.5 mL, (group S+ with, group S without an infusion at 2.5 mL hr-1) or sufentanil 2 micrograms mL-1 + clonidine 3 micrograms mL-1, demand dose 5 micrograms sufentanil + 7.5 micrograms clonidine i.e. 2.5 mL (group SC+ with and SC without an infusion of 2.5 ml hr-1). The other PCA settings (Bard I PCA pump) were a lock out of interval of 10 min and a 1 h limit of 20 micrograms sufentanil and 30 micrograms clonidine i.e. 10 mL. The parameters measured were the analgesic drug consumption and number of dose demands during the first 24 h, pain scores at 6 h intervals, side effects and quality of sleep. The concurrent infusion increased the dose requirements regardless of the content of the syringe. Consumption of sufentanil was ...Continue Reading

References

Nov 1, 1990·Anesthesiology·R MendezK Kashtan
Oct 1, 1989·British Journal of Anaesthesia·F BonnetM Ghignone

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Citations

May 29, 2013·European Journal of Pharmacology·Shaifali BhallaAnil Gulati
Oct 15, 2011·Pharmacology·Shridhar V Andurkar, Anil Gulati
Sep 26, 2014·Plastic and Reconstructive Surgery·Eric B Rosero, Girish P Joshi

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