PMID: 41060Sep 1, 1979

Potentiation of the diabetogenic effect of streptozocin by phentolamine in the rat

The Journal of Pharmacy and Pharmacology
P K TalwalkerR S Grewal

Abstract

The effect of alpha- and beta-adrenoceptor blocking agents and a beta2-agonist, salbutamol, on the diabetogenic effects of streptozocin (threshold doses) was investigated in the rat. Phentolamine and salbutamol potentiated the diabetogenic effect of streptozocin but phenoxybenzamine, tolazoline, oxprenolol and propranolol were without effect. The potentiating effect of phentolamine was blocked by oxprenolol. Potentiation of the diabetogenic effect by phentolamine is not related to alpha-adrenoceptor block, vasodilatation or insulin release. But it may be related to its ability to stimulate beta-adrenoceptors.

Related Concepts

Z-Max
Tolazoline
Zanosar
Oxprenolol
Streptozotocin Diabetes
Adrenergic Receptor
NEUROD1 wt Allele
Propranolol
Phentolamine
Agonist

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