PMID: 2496081Mar 1, 1989Paper

Potentiation of the exercise pressor reflex by muscle ischemia

Journal of Applied Physiology
C L Stebbins, J C Longhurst

Abstract

The reflex responses to static contraction are augmented by ischemia. The metabolic "error signals" that are responsible for these observed responses are unknown. Therefore this study was designed to test the hypothesis that static contraction-induced pressor responses, which are enhanced during muscle ischemia, are the result of alterations in muscle oxygenation, acid-base balance, and K+. Thus, in 36 cats, the pressor response, active muscle blood flow, and muscle venous pH, PCO2, PO2, lactate, and K+ were compared during light and intense static contractions with and without arterial occlusion. During light contraction (15-16% of maximal), active muscle blood flow increased without and decreased with arterial occlusion (+35 +/- 12 vs. -60 +/- 11%). Arterial occlusion augmented these pressor responses by 132 +/- 25%. Without arterial occlusion, changes (P less than 0.05) were seen in PO2, O2 content, PCO2, and K+. Lactate and pH were unchanged. With arterial occlusion, changes in muscle PCO2 were augmented and significant changes were seen in pH and lactate. During intense static contraction (67-69% of maximal), muscle blood flow decreased without arterial occlusion (-39 +/- 9%) and decreased further during occlusion (-81 +/-...Continue Reading

Citations

Dec 17, 2002·Journal of Applied Physiology·Ramy L Hanna, Marc P Kaufman
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·W HildebrandtJ Stegemann
Jan 1, 1996·Archives of Physiology and Biochemistry·M C Zattara-Hartmann, Y Jammes
Jul 23, 2005·Journal of Applied Physiology·Lawrence I Sinoway, Jianhua Li
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Angela E KindigMarc P Kaufman
Apr 27, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hirotsugu TsuchimochiMarc P Kaufman
Jun 13, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven W CoppMarc P Kaufman
Aug 17, 2002·Journal of Applied Physiology·Ramy L HannaMarc P Kaufman
Mar 16, 2002·Journal of Applied Physiology·Shawn G Hayes, Marc P Kaufman
Mar 24, 2007·Journal of Applied Physiology·Zhaohui GaoJianhua Li
Feb 10, 2010·The Journal of Physiology·Scott A SmithMary G Garry
Nov 15, 2014·Medicine and Science in Sports and Exercise·Kyung-Ae KimJong-Kyung Kim
Apr 26, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Steven W CoppMarc P Kaufman
Mar 31, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Stephanie C Tjen-A-Looi, Christopher A Longhurst
Nov 12, 2005·Experimental Physiology·Scott A SmithMary G Garry

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