PMID: 9184814May 1, 1997Paper

Potentiation of the relaxing action of isoproterenol by forskolin in rabbit aortic rings: the involvement of beta 2-adrenoceptors

General Pharmacology
N Satake, S Shibata

Abstract

1. Forskolin, an activator of adenylate cyclase, potentiated the relaxing response to isoproterenol in rabbit aortic rings precontracted by phenylephrine (PE). 2. The potentiating effect of forskolin was inhibited by propranolol, a beta-adrenoceptor inhibitor, but not by methylene blue, a guanylate cyclase inhibitor. 3. The relaxing response to terbutaline, a beta 2-adrenoceptor agonist, but not lower concentrations of dobutamine, a beta 1-adrenoceptor agonist, also was potentiated by forskolin. Forskolin, however, potentiated the relaxing response to high concentrations of dobutamine, which activates both beta 1- and beta 2-adrenoceptors. 4. Yohimbine, an alpha 2-adrenoceptor inhibitor, glyburide, an ATP-sensitive K+ channel inhibitor, iberiotoxin, a Ca(2+)-activated K+ channel inhibitor, or endothelium-removal failed to affect the potentiating effect of forskolin. 5. Dibutyryl cyclic AMP (cAmp) also potentiated the relaxing response to terbutaline. 6. These results suggest that in rabbit aortic rings forskolin causes the apparent potentiation of isoproterenol-induced relaxation by mainly affecting the relaxing response due to the activation of beta 2-adrenoceptors by the forskolin-induced increase in the level of cAMP.

References

Jan 10, 1991·European Journal of Pharmacology·D H MauriceR J Haslam
Dec 4, 1990·European Journal of Pharmacology·D H Maurice, R J Haslam
Mar 22, 1988·European Journal of Pharmacology·G C GraceG J Dusting
Apr 24, 1986·The New England Journal of Medicine·H Rasmussen
Jan 16, 1989·Biochemical and Biophysical Research Communications·R M Palmer, S Moncada
Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K B SeamonJ W Daly
Oct 1, 1983·Canadian Journal of Physiology and Pharmacology·R V Vegesna, J Diamond

❮ Previous
Next ❯

Citations

May 26, 2016·Life Sciences·Mónica Moreira-RodriguesDaniel Moura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.