PMID: 3750343Jan 1, 1986Paper

Potentiation of the toxicity of basic peptides from rattlesnake venoms by sodium acetate

Toxicon : Official Journal of the International Society on Toxinology
H R AllenC R Geren

Abstract

The potentiating effect of sodium acetate on the toxicity of crotamine from Crotalus durissus terrificus venom, E toxin from Crotalus horridus horridus venom, and myotoxin a from Crotalus viridus viridis venom was examined. Subcutaneous injection of 6.3 mg/kg body weight of either crotamine or E toxin in 0.6 ml of water or myotoxin a in 0.6 ml of 0.05 M Tris/0.1 M NaCl buffer, pH 9.0, failed to produce lethality in mice. Injection of either E toxin or crotamine at doses of 4.0 mg/kg in 0.6 ml of 20 mM phosphate, pH 7.2, containing 1 M sodium chloride also failed to produce lethality. However, when any of the toxins were injected in 0.4 ml of 1 M sodium acetate, pH 7.0, lethality was observed. LD50 values of 1.43 mg/kg for E toxin, 1.39 mg/kg for crotamine and 0.56 mg/kg for myotoxin a were determined under these conditions. Lethality was also observed when either sodium propionate or sodium butyrate was used as a carrier for E toxin. The effect of these two buffers on crotamine and myotoxin a was not examined. Injection of E toxin s.c. in water followed at various time intervals with i.p. injections of 1 M sodium acetate produced lethality, even when the acetate was injected up to 4 hr after the toxin challenge.

References

Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·O G HampeJ M Gonçalves
Jan 1, 1979·Toxicon : Official Journal of the International Society on Toxinology·O V BrazilC J Laure
Jan 1, 1979·Preparative Biochemistry·J Sullivan, C R Geren
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·N MaedaF E Russell
Jul 1, 1971·Toxicon : Official Journal of the International Society on Toxinology·J CheymolM Roch-Arveiller
Jan 1, 1983·Toxicon : Official Journal of the International Society on Toxinology·S J Hong, C C Chang
Jan 1, 1983·Toxicon : Official Journal of the International Society on Toxinology·D MebsY Samejima

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Citations

Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·C L OwnbyI I Kaiser
Apr 1, 1996·Toxicon : Official Journal of the International Society on Toxinology·M P O'KeefeR A Nieman
Nov 22, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Boni-MitakeJ R Rogero

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