Potentiation of tricyclic antidepressant toxicity by physostigmine in mice

Clinical Toxicology
M A VanceJ B Blumberg

Abstract

Subtoxic doses of physostigmine have been found to potentiate the convulsive toxicity and lethality of amitriptyline and imipramine in CD1 and B6A mice. Neostigmine failed to potentiate the toxicity and lethality of imipramine. Physostigmine tended to protect mice against atropine-induced lethality. These data suggest the site of toxicity of this drug-drug interaction between the tricyclic antidepressants and physostigmine may be occurring in the CNS through a mechanism distinct from the anticholinergic actions of the antidepressants.

References

Mar 26, 1976·Science·N SitaramJ C Gillin
Jan 1, 1975·The Journal of Pediatrics·J Di LibertiT Turner
Mar 1, 1975·Archives of General Psychiatry·R P Granacher, R J Baldessarini
Mar 3, 1975·JAMA : the Journal of the American Medical Association·R W Newton
Feb 1, 1973·The American Journal of Psychiatry·M K el-YousefH J Sekerke
Feb 1, 1971·The American Journal of Psychiatry·J F Heiser, J C Gillin
Sep 1, 1971·Clinical Toxicology·T L SlovisW Lipscomb
Mar 1, 1961·Clinical Pharmacology and Therapeutics·C CLEMMESEN, E NILSSON

Citations

Jul 23, 2003·Journal of Toxicology. Clinical Toxicology·Robert S Hoffman
Jan 1, 1997·Journal of Toxicology. Clinical Toxicology·J PerroneM M Stecker
May 1, 1980·Clinical Toxicology·W K SummersJ M Fischer
Sep 3, 1998·The American Journal of Emergency Medicine·A L WeinerE Starr
Jul 1, 1991·The Journal of Emergency Medicine·M J Smilkstein
Jun 11, 1998·Emergency Medicine Clinics of North America·M B Miller
Aug 1, 1992·Journal of the American Geriatrics Society·J Francis
Sep 2, 2006·Journal of Intensive Care Medicine·David P BettenRichard F Clark
Nov 25, 2003·Emergency Medicine·Geoffrey K IsbisterIan M Whyte
May 20, 2003·Radiation Research·Jie-Young SongYeon-Sook Yun
Mar 1, 1983·Acta Pharmacologica Et Toxicologica·P Zandberg, B Sangster
Mar 1, 1986·Medical Toxicology·P R Pentel, N L Benowitz
Mar 4, 1991·The Medical Journal of Australia·L J Dziukas, J Vohra

Related Concepts

Amitriptyline Hydrochloride
Tricyclic Antidepressive Agents
Dose-Response Relationship, Drug
Drug Augmentation
Tofranil
Lethal Dose 50
Mice, Inbred Strains
Eserine

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