Potentiation of vesicular stomatitis New Jersey virus infection in mice by mosquito saliva

Parasite Immunology
K H LimesandB J Beaty

Abstract

Saliva of arthropod vectors can modulate vertebrate host immunological functions in many ways. To investigate if vesicular stomatitis New Jersey virus (VSNJ) infection could be potentiated by arthropod saliva, mice in three different age groups (3 days, 3 weeks, or > 8 months) were exposed to VSNJ-infected mosquitoes or were needle injected with an equivalent dose of VSNJ (titre 1.5-3 logs). Previous studies have demonstrated that VS viruses do not replicate in mice older than 3 weeks of age. Infection was monitored by examining serum for the presence of VSNJ at 2 days postinfection (PI) or for neutralizing antibody on days 7 and 14 PI. All 3-day-old mice succumbed to viral infection by mosquito transmission or delivery by injection. Ninety-four percent of the 3-week-old mice bitten by infected mosquitoes developed antibody, whereas antibody was detected in only 13% of inoculated mice. Adult mice developed neutralizing antibody (73%) when fed upon by infected mosquitoes, but only 11% developed antibody when virus was injected. Day 2 serum samples from 3-week and adult age groups were negative by virus isolation. These data indicate that mosquito mediated delivery of VSNJ exacerbates virus infection in mice older than 3 weeks.

References

Mar 18, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Bradley S Schneider, Stephen Higgs
Nov 15, 2001·Veterinary Parasitology·Stephen Wikel, F J Alarcon-Chaidez
Sep 13, 2002·Insect Biochemistry and Molecular Biology·J G Valenzuela
Mar 15, 2011·Vector Borne and Zoonotic Diseases·Bradley S SchneiderSalaheddine Mécheri
Mar 24, 2006·Viral Immunology·Bradley S SchneiderStephen Higgs
Dec 7, 2006·Biology Letters·Peter F BillingsleyV J Johnston
Mar 7, 2007·Infection and Immunity·Michael J DonovanMary Ann McDowell
Dec 15, 2010·Journal of Virology·Linda M StyerKristen A Bernard
Apr 27, 2013·Virology Journal·R C ChristoffersonC N Mores
Sep 29, 2011·Parasites & Vectors·Albin FontaineLionel Almeras
Jun 21, 2013·PLoS Neglected Tropical Diseases·Alain Le CoupanecValérie Choumet
Apr 14, 2012·Tropical Medicine and Health·Lyre Anni Espada-Murao, Kouichi Morita
Jun 21, 2014·PeerJ·Christopher J Lehiy, Barbara S Drolet
Nov 3, 2014·Annual Review of Virology·Michael J ConwayErol Fikrig
Aug 29, 2003·Journal of Medical Entomology·William K ReisenFarida Mahmood
Apr 16, 2003·Journal of Medical Entomology·William K ReisenThomas Laver
Jul 22, 2014·Virology·Laurence BriantDorothée Missé
Feb 13, 2015·Vector Borne and Zoonotic Diseases·Stephen Higgs, Dana L Vanlandingham
Jun 3, 2006·Journal of Medical Entomology·Adalberto A Pérez De LeónWalter J Tabachnick
Apr 13, 2007·Journal of Medical Entomology·Kathrin F A LangnerIrene Greiser-Wilke
Sep 16, 2016·PLoS Neglected Tropical Diseases·Michael J ConwayTonya M Colpitts
Oct 16, 2015·Journal of Virology·Lindsey A MoserKristen A Bernard
Apr 12, 2019·Journal of Virology·Andrew K HastingsErol Fikrig
Sep 26, 2014·PLoS Neglected Tropical Diseases·Christopher F BosioB Joseph Hinnebusch
Feb 8, 2019·Frontiers in Microbiology·Yan-Jang S HuangDana L Vanlandingham

Citations

Jan 1, 1976·The American Journal of Tropical Medicine and Hygiene·D J Gubler, L Rosen
Jan 1, 1976·The American Journal of Tropical Medicine and Hygiene·I K Liu, Y C Zee
Jul 1, 1989·Experimental Parasitology·J M Ribeiro
Jan 1, 1982·Annual Review of Entomology·Stephen Wikel
Oct 1, 1995·The American Journal of Tropical Medicine and Hygiene·J A VanleeuwenD Waltner-Toews
Jan 1, 1995·Annual Review of Entomology·J O CarlsonB J Beaty
Feb 1, 1994·International Journal for Parasitology·Stephen WikelD K Bergman
Apr 1, 1996·The American Journal of Tropical Medicine and Hygiene·J E OsorioT M Yuill
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·A M PowersB J Beaty
Jun 1, 1996·The American Journal of Tropical Medicine and Hygiene·A A QureshiE A Lerner
May 23, 1998·The American Journal of Tropical Medicine and Hygiene·Stephen HiggsCarol D Blair
Jun 6, 1998·Journal of Medical Entomology·J F EdwardsB J Beaty
Jul 4, 1998·Parasitology·V HajnickáP A Nuttall
Apr 12, 2000·Parasite Immunology·V HajnickáP A Nuttall
Feb 24, 2001·Annals of the New York Academy of Sciences·Walter J Tabachnick
May 1, 1990·Parasitology Today·R G Titus, J M Ribeiro

Related Concepts

Vertebrates
Tumor Virus Infections
Antibodies, Viral
Virus Diseases
Arthropod Vectors
Saliva - SpecimenType
Antibodies, Neutralizing
Insect Vectors
Chandipura virus
Mouse, Inbred ICRC

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.