PMID: 11328655May 1, 2001Paper

POU genes in metazoans: homologs in sea anemones, snails, and earthworms

DNA Sequence : the Journal of DNA Sequencing and Mapping
D ShahG W Stuart

Abstract

Previously undescribed POU genes were detected in several invertebrate phyla using redundant primers in a polymerase chain reaction (PCR) that targeted highly conserved sequences encoding known POU-domains. A class IV gene and a gene tentatively assigned to class VI were identified in sea anemones (Condylactis), two distinct class III genes were identified in snails (Biomphalaria), and a single class IV gene was identified in earthworms (Lumbricus). The identification of POU genes in cnidarians, mollusks, and annelids completes a survey of the major metozoan phyla. As POU genes exist in all of these organisms, they appear to be a fundamental characteristic of the metazoan lineage, and may have played a major role in the diversification of these organisms.

References

Jun 1, 1991·Mechanisms of Development·A N BillinS J Poole
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T DickW Chia
Aug 19, 1995·Gene·G W StuartM W King
May 15, 1997·Genes & Development·A K Ryan, M G Rosenfeld
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·M XiangJ Nathans

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