Abstract
In this work, we have designed and investigated a new carrier for dermal and transdermal drug delivery. The delivery system is composed of high (>60 %) ethanol concentration, phospholipid, polymer, and water. The system forms a structured matrix following non-occluded application on the skin. We call these structured carriers as pouch drug delivery systems (PDDS). The pouch-structured matrix was characterized by electron microscopy, (31)P-NMR and FTIR. The new delivery system exhibits a number of properties adequate for the design of improved dermal and transdermal drug administration for various treatments. Lidocaine PDDS dry faster and has an enhanced dermal drug delivery when compared to a clinical-used product. These proprieties are important for the prevention of premature ejaculation. Results obtained in pharmacodynamics test carried out with brotizolam PDDS in a mice-sleeping model and with ibuprofen PDDS in fevered rats indicated a prolonged hypnotic and antipyretic effect, respectively. The carrier was found nonirritant in tests carried out on EpiDerm(TM) skin model.
References
Aug 1, 1972·Toxicology and Applied Pharmacology·J J LouxS L Yankell
Apr 1, 1996·Journal of Pharmaceutical Sciences·P B Laub, J M Gallo
May 1, 1997·Microscopy Research and Technique·N A Monteiro-RiviereD W Hobson
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·E TouitouM Eliaz
Aug 5, 2000·Biomaterials·N Dayan, E Touitou
Aug 13, 2003·Critical Reviews in Therapeutic Drug Carrier Systems·Biana Godin, Elka Touitou
Jan 28, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·B Godin, E Touitou
Mar 17, 2004·Advanced Drug Delivery Reviews·Adrian C Williams, Brian W Barry
Jun 7, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Donatella PaolinoMassimo Fresta
Sep 29, 2005·Drug Delivery·Denize Ainbinder, Elka Touitou
Apr 6, 2006·Chemical & Pharmaceutical Bulletin·Kaname HashizakiNaotake Ogawa
Jan 12, 2008·Alternatives to Laboratory Animals : ATLA·Horst SpielmannValérie Zuang
Jul 15, 2009·Journal of Visualized Experiments : JoVE·Helena KandárováJohn Sheasgreen
Dec 8, 2009·International Journal of Pharmaceutics·Margarita Shumilov, Elka Touitou
Aug 25, 2010·Pharmaceutical Biology·Anofi Omotayo Tom AshafaAnthony Jide Afolayan
Mar 15, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Donatella PaolinoMassimo Fresta
Jul 16, 2013·Archives of Pharmacal Research·Chung-Il LeeKi-Wan Oh
Feb 1, 2011·Drug Delivery and Translational Research·Denize Ainbinder, Elka Touitou