PMID: 3767400Oct 1, 1986Paper

Povidone-iodine in polyethylene oxide hydrogel dressing. Effect on multiplication of Staphylococcus aureus in partial-thickness wounds

Archives of Dermatology
P M MertzM A Kuglar

Abstract

We studied the ability of a polyethylene oxide hydrogel dressing (Vigilon) containing povidone-iodine to prevent Staphylococcus aureus proliferation in partial-thickness wounds. We previously reported that a single application of povidone-iodine on wounds challenged with 2 X 10(6) S aureus was not effective in reducing the number of S aureus after 24 hours. It was therefore hypothesized that povidone-iodine might be effective if it was available continuously and applied to wounds containing a smaller number of bacteria. To test this hypothesis, we made multiple partial-thickness wounds (5 X 7 X 0.3 mm) on six domestic pigs. We then inoculated the wounds by scrubbing them with either a low concentration (log 3.5) or a high concentration (log 7) of S aureus suspension. The wounds were either treated with Vigilon or Vigilon containing povidone-iodine or left air exposed. Wounds from each of these treatment groups were cultured by the scrub technique for S aureus with a 0.5% sodium thiosulfate-polysorbate (Tween) 80 solution 5 minutes, 30 minutes, 24 hours, or 48 hours later. A significant reduction in the number of S aureus recovered from wounds treated with Vigilon containing povidone-iodine was seen with the group inoculated wit...Continue Reading

Citations

Oct 19, 2005·Archives of Dermatological Research·Stephen C DavisPatricia M Mertz
May 29, 2012·Journal of Materials Science. Materials in Medicine·Abbas YariHadi Bakhshi
Jun 6, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Catherine Harrison-BalestraPatricia M Mertz
Dec 4, 2012·International Journal of Pediatric Otorhinolaryngology·Carolyn P Ojano-DirainPatrick J Antonelli
Sep 14, 2013·International Wound Journal·Priscilla L PhillipsGregory S Schultz
May 1, 1987·Archives of Environmental Health·P M Ridker

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