PMID: 15219158Jun 29, 2004Paper

Power calculations for the transmission/disequilibrium and affected sib pair tests using elementary probability methods

Genetical Research
Barry W Brown

Abstract

The transmission/disequilibrium test (TDT) and the affected sib pair test (ASP) both test for the association of a marker allele with some conditions. Here, we present methods for calculating the probability of detecting the association (power) for a study examining a fixed number of families for suitability for the study and for calculating the number of such families to be examined. Both calculations use a genetic model for the association. The model considered posits a bi-allelic marker locus that is linked to a bi-allelic disease locus with a possibly nonzero recombination fraction between the loci. The penetrance of the disease is an increasing function of the number of disease alleles. The TDT tests whether the transmission by a heterozygous parent of a particular allele at a marker locus to an affected offspring occurs with probability greater than 0.5. The ASP tests whether transmission of the same allele to two affected sibs occurs with probability greater than 0.5. In either case, evidence that the probability is greater than 0.5 is evidence for association between the marker and the disease. Study inclusion criteria (IC) can greatly affect the necessary sample size of a TDT or ASP study. IC considered by us include a...Continue Reading

Citations

Apr 5, 2007·Journal of Genetics·Najla KharratAhmed Rebaï
May 22, 2008·European Journal of Human Genetics : EJHG·Michelle LucianoRobert Plomin
Aug 10, 2007·Environmental Health Perspectives·John B WhitfieldNicholas G Martin

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