Power-Doppler perfusion phenotype in RA patients is dependent on anti-citrullinated peptide antibody status, not on rheumatoid factor

Rheumatology International
Ottar GadeholtE C Schwaneck

Abstract

It is not known whether there are any consistent non-serological differences between seropositive and seronegative rheumatoid arthritis, and if any, whether they depend upon rheumatoid factor (RF), anti-citrullinated peptide antibodies (ACPA), or both. In a pilot study, we showed that the two forms could be differentiated using power-Doppler sonography (PDS), and that the difference is ACPA dependent. This extended study explored whether the previous findings could be confirmed. 103 patients 51 ACPA positive (ACPA +), 52 ACPA negative (ACPA -) with active wrist arthritis were examined using PDS. By means of a temporal image series, pulsatility was evaluated over a 3-5-s period, maximum and minimum perfusion signal were determined using a computer program counting the number of coloured pixels for each frame. Maxima (Pmax) and minima (Pmin) were determined, and the standardized peak-to-peak amplitude sA was calculated (sA = (Pmax - Pmin)/Pmax). This parameter was then compared for ACPA + and ACPA- patients. In addition, a multivariate regression was performed, to determine which factors influence sA. sA differed significantly between ACPA + and ACPA- patients [20% (13-26) vs. 41% (32-57), p < 0. 0001]. In the multivariate analys...Continue Reading

References

Aug 1, 1965·Arthritis and Rheumatism·S D LITWIN, J M SINGER
Dec 1, 1961·Arthritis and Rheumatism·C RAGAN
Sep 30, 2005·Archives of Gerontology and Geriatrics·Nuran TurkcaparMurat Duman
Dec 16, 2010·Annals of the Rheumatic Diseases·Leonid PadyukovUNKNOWN Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study group
Oct 29, 2011·Arthritis Research & Therapy·Diederik P C De RooyAnnette H M Van der Helm-van Mil
Oct 19, 2014·Annals of the Rheumatic Diseases·Carolin HechtStephanie Finzel
Dec 8, 2014·Best Practice & Research. Clinical Rheumatology·Arthur G Pratt, John D Isaacs

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Citations

May 28, 2019·Clinical Rheumatology·Gadeholt OttarPfeil Alexander

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