Power spectral analysis of electroencephalographic desynchronization induced by cocaine in rats: correlation with evaluation of noradrenergic neurotransmission at the medial prefrontal cortex

Synapse
A Y ChangS H Chan

Abstract

We applied continuous, on-line and real-time spectral analysis of electroencephalographic (EEG) signals and microdialysis to evaluate the possible participation of noradrenergic neurotransmission at the medial prefrontal cortex (mPFC) in EEG desynchronization induced by cocaine. Male Sprague-Dawley rats that were under chloral hydrate anesthesia were used. Intravenous administration of cocaine (1.5 or 3.0 mg/kg) dose-dependently induced EEG desynchronization, as represented by a decrease in root mean square (RMS) and an increase in mean power frequency (MPF) value of the EEG signals. Power spectral analysis further revealed that whereas both doses of cocaine promoted a reduction in the alpha (8-13 Hz), theta (4-8 Hz), and delta (1-4 Hz) components, the lower dose of cocaine decreased, and the higher dose increased the beta band (13-32 Hz). Microdialysis data indicated an elevation in extracellular concentration of norepinephrine at the mPFC that paralleled temporally and correlated positively with the maximal effect of cocaine on EEG activity. Bilateral microinjection of the selective noradrenergic neurotoxin, DSP4 (50 micrograms), or equimolar concentration (500 pmol) of the alpha 1-adrenoceptor antagonist, prazosin, or alpha ...Continue Reading

References

Sep 3, 1976·Brain Research·D H VersteegM Palkovits
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·D KemaliF Starace
Dec 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·W KropfJ Krieglstein
Nov 12, 1986·European Journal of Pharmacology·D K Pitts, J Marwah
Nov 1, 1971·Neuropharmacology·M B Wallach, S Gershon
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D S Segal, A J Mandell
Dec 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·B RouotJ Schwartz
Aug 19, 1983·Science·N E Goeders, J E Smith
Jan 1, 1993·Brain Research Bulletin·V M KumarS K Manchanda

❮ Previous
Next ❯

Citations

Apr 20, 2001·Neurotoxicology·L S TonduliP Monmaur
May 1, 1996·British Journal of Pharmacology·J Y ChanS H Chan
Sep 10, 2002·Anesthesiology·Robert A WhittingtonHisayo O Morishima
Dec 6, 2006·Neuroscience and Biobehavioral Reviews·Gennady G Knyazev
Oct 7, 2004·Neuroscience and Biobehavioral Reviews·Filippo S GiorgiFrancesco Fornai
Oct 25, 2011·Neuroscience and Biobehavioral Reviews·Gennady G Knyazev
Jun 1, 2005·Neuron·Boris Y MileykovskiyJerome M Siegel
Sep 29, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Junseok A Kim, Karen D Davis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.