Power training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle.

Age
Eija PöllänenVuokko Kovanen

Abstract

At the moment, there is no clear molecular explanation for the steeper decline in muscle performance after menopause or the mechanisms of counteractive treatments. The goal of this genome-wide study was to identify the genes and gene clusters through which power training (PT) comprising jumping activities or estrogen containing hormone replacement therapy (HRT) may affect skeletal muscle properties after menopause. We used musculus vastus lateralis samples from early stage postmenopausal (50-57 years old) women participating in a yearlong randomized double-blind placebo-controlled trial with PT and HRT interventions. Using microarray platform with over 24,000 probes, we identified 665 differentially expressed genes. The hierarchical clustering method was used to assort the genes. Additionally, enrichment analysis of gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was carried out to clarify whether assorted gene clusters are enriched with particular functional categories. The analysis revealed transcriptional regulation of 49 GO/KEGG categories. PT upregulated transcription in "response to contraction"-category revealing novel candidate genes for contraction-related regulation of muscle funct...Continue Reading

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Citations

Mar 26, 2013·Pflügers Archiv : European journal of physiology·Séverine LamonKristian Vissing
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Datasets Mentioned

BETA
GSE16907

Methods Mentioned

BETA
hormone replacement therapy
biopsies
biopsy
chip
electrophoresis
PCR

Clinical Trials Mentioned

ISRCTN49902272

Software Mentioned

Limma
package
MIAME
BeadStudio Direct
PatternViewer
Bioconductor
Affy
R

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