PMID: 6105439Aug 9, 1980Paper

Powerful effect of HL-DR matching on survival of cadaveric renal allografts

Lancet
A Ting, P J Morris

Abstract

Matching for HLA-DR antigens seems to be an effective method of improving the survival rate of cadaveric donor renal allografts; this was shown in the analysis of 190 cadaver transplants in one unit. Patients receiving kidneys well-matched for HLA-DR (no incompatibilities) had a significantly better survival rate (85% at 1 year) than patients with 1 or 2 incompatibilities (64% and 56% respectively, at 1 year). This high survival rate of the DR matched grafts was not due to coincidental better matching of the HLA-A and B antigens. DR matching seems to improve graft survival even in patients who have never been transfused or not. Matching for the limited number of DR antigens mostly with a relatively high antigen frequency should simplify the matching procedure for selection of donor-recipient pairs in cadaveric transplantation.

References

May 13, 1978·Lancet
Apr 15, 1978·Lancet·D AlbrechtsenE Thorsby

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Citations

Jul 1, 1990·Transplant International : Official Journal of the European Society for Organ Transplantation·T SchmidR Margreiter
Sep 1, 1987·The Japanese Journal of Surgery·P J Morris
Oct 1, 1990·Immunology Letters·S C ChangC Y Lin
Jan 1, 1988·Social Science & Medicine·B J O'Brien
Feb 19, 1981·The New England Journal of Medicine
Jun 1, 1983·The Journal of Experimental Medicine·G Mayrhofer, M A Schon-Hegrad
Mar 13, 1982·British Medical Journal·P J DewarR M Taylor
Dec 1, 1981·Journal of Medical Genetics·A M MacLeodG R Catto
Feb 1, 1981·Immunology Today·A Ting
Dec 1, 1980·Immunology Today·W M BaldwinJ J Van Rood
Oct 1, 1988·The British Journal of Surgery·G LaufferP J Morris
Jan 1, 1988·The British Journal of Surgery·R M JonesP J Morris
Jan 1, 1982·Immunological Reviews·P J Morris, A Ting
Sep 1, 1981·Tissue Antigens·H ScottE Thorsby
Aug 1, 1996·Japanese Journal of Medical Science & Biology·S ShintakuK Dohi
Dec 19, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Sapir-PichhadzeS J Kim
Apr 16, 2004·Transplantation·Peter J Morris, Anthony P Monaco
Apr 16, 2004·Transplantation·Ilias I N DoxiadisFrans H J Claas
Feb 1, 1986·Tissue Antigens·R F DoverenW A Buurman
May 1, 1985·Tissue Antigens·A Ting, P J Morris
Jul 4, 1988·The Medical Journal of Australia·R G WalkerP Kincaid-Smith
May 1, 1990·Kidney International·G Sunder-PlassmannC P Worman
Sep 1, 1984·Kidney International·T B Strom

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