Powering a two-stroke RNA engine

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Powering a two-stroke RNA engine

Abstract

References

The U5 and U6 small nuclear RNAs as active site components of the spliceosome

Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing

Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly

Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants

A pathway of sequential arginine-serine-rich domain-splicing signal interactions during mammalian spliceosome assembly

Prp8 protein: at the heart of the spliceosome

Structural insights into translational fidelity

The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing

Insights into the mechanisms of splicing: more lessons from the ribosome

Repositioning of the reaction intermediate within the catalytic center of the spliceosome

Exon ligation is proofread by the DExD/H-box ATPase Prp22p.

RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans

A simple principle to explain the evolution of pre-mRNA splicing

Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing

U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing

The Prp18 protein stabilizes the interaction of both exons with the U5 snRNA during the second step of pre-mRNA splicing

RS domain-splicing signal interactions in splicing of U12-type and U2-type introns

Related Concepts

Related Feeds

Alternative splicing

Related Papers

CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.

"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.

The spliceosome: caught in a web of shifting interactions

Mechanistic insights from reversible splicing catalysis.

RS domain-splicing signal interactions in splicing of U12-type and U2-type introns