PMID: 9183748Jun 20, 1997Paper

pox-neuro is required for development of chemosensory bristles in Drosophila

Journal of Neurobiology
T Awasaki, K Kimura

Abstract

The gene pox-neuro (poxn), which encodes a possible transcriptional regulator including a paired domain, specifies the differences between monoinnervated and polyinnervated sensory organs in the embryo. A detailed analysis of this gene, and in particular, an analysis of its function in the adult sensory organs, has so far been hampered by the unavailability of loss-of-function mutations. Here, we report the isolation of loss-of-function mutations of poxn and show that the chemosensory bristles are transformed into mechanosensory bristles in mutant flies. The external morphology of putative chemosensory bristles, number of innervating neurons, and cell division pattern are all affected in the mutants, showing that poxn is strictly required for development of the adult chemosensory bristles. In addition, the formation of some precursor cells is suppressed in the mutants, suggesting that poxn is also required for formation of the precursors of chemosensory bristles.

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A KassisN Perrimon
Mar 22, 1991·Cell·P Heitzler, P Simpson
Nov 1, 1990·Developmental Biology·V Hartenstein, J W Posakony
Aug 1, 1989·Trends in Genetics : TIG·A Ghysen, C Dambly-Chaudiere
May 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Ghysen, C Dambly-Chaudière
Jan 1, 1993·Developmental Biology·K RayV Rodrigues
May 1, 1993·Genes & Development·A GhysenY N Jan
Jun 1, 1993·Developmental Biology·A L Parks, M A Muskavitch
Jul 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Lewis I Held

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Citations

Apr 17, 2007·Pflügers Archiv : European journal of physiology·Maurice J Kernan
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ryan M JosephUlrike Heberlein
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Monica DusGreg S B Suh
Dec 15, 2012·PloS One·David J MellertBruce S Baker
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tsuyoshi Inoshita, Teiichi Tanimura
May 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ivan OstojicJoy Alcedo
Apr 24, 2008·Proceedings. Biological Sciences·Andrew I BarnesTracey Chapman
Mar 17, 2006·Journal of Neurogenetics·Kazue Usui-AokiDaisuke Yamamoto
Apr 20, 2014·Science China. Life Sciences·Fei SunLi Liu
Mar 26, 2015·Nature Communications·Emily E LeDueMichael D Gordon
Dec 17, 2009·Current Biology : CB·Anita V Devineni, Ulrike Heberlein
Mar 29, 2002·Journal of Neurobiology·Masayuki Koganezawa, Ichiro Shimada
Apr 7, 2010·Nature·Peter CameronKristin Scott
Jul 27, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jessica E Treisman
Aug 3, 2004·Genesis : the Journal of Genetics and Development·Sophie LayalleChristine Dambly-Chaudière
Jul 8, 2017·The Journal of Experimental Biology·Satoshi MurataTeiichi Tanimura
Jan 7, 2017·The Journal of Experimental Biology·Pavan RamdyaJoel D Levine
Nov 6, 1998·FEBS Letters·G Hassanzadeh GhC Dambly-Chaudière
Nov 21, 2018·Journal of Neurogenetics·Ken-Ichi KimuraDaisuke Yamamoto
Nov 11, 2005·Nature·Ken-Ichi KimuraDaisuke Yamamoto
Sep 13, 2019·The Journal of Experimental Biology·Yu-Chieh David ChenAnupama Dahanukar
Mar 20, 2020·Nature Communications·Peter KerwinAnne C von Philipsborn
Mar 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Farhan AbuGreg S B Suh
Nov 9, 2018·Frontiers in Cellular Neuroscience·Yu-Chieh David ChenAnupama Dahanukar
Jan 29, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Sophie LayalleChristine Dambly-Chaudière
Mar 1, 2013·The Journal of Experimental Biology·Sören DiegelmannBertram Gerber
Mar 10, 2000·Science·P J ClyneJ R Carlson

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