Pox-Protein Public Private Partnership program and upcoming HIV vaccine efficacy trials

Current Opinion in HIV and AIDS
Nina D Russell, Mary A Marovich

Abstract

The purpose of review is to provide an overview of the Pox-Protein Public Private Partnership (P5) and highlight the progress of the P5 program, including an upcoming HIV vaccine efficacy trial in South Africa. The RV144 Thai vaccine efficacy trial was the first to demonstrate that an HIV-1 vaccine can prevent HIV acquisition. The P5 vaccine regimen uses an ALVAC prime and protein boost modeled after the RV144 vaccine and adapted for the subtype C virus predominant in the southern African region. This regimen was recently tested in the HIV Vaccine Trials Network 100 phase 1/2a study in South Africa. Based on prospectively defined immunogenicity thresholds, criteria were met to support the launch of an efficacy study in late 2016. The aim of this phase 2b/3 trial will be to improve upon the results of RV144, with increased and more durable vaccine efficacy, to accelerate the potential licensure of a preventive vaccine in southern Africa. The planned P5 efficacy trial, HIV Vaccine Trials Network 702, is designed to test and prospectively define correlates of protection, if efficacious. A vaccine with modest efficacy, vaccine efficacy at least 50%, could have substantial public health impact and significantly decrease the incidenc...Continue Reading

References

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Citations

Jan 5, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mina C HosseinipourUNKNOWN HVTN 111 Protocol Team
Apr 15, 2019·International Journal of Public Health·Christian SelingerAnna Bershteyn
Aug 14, 2019·Journal of the International AIDS Society·Blythe AdamsonDobromir Dimitrov
Jan 30, 2021·Open Forum Infectious Diseases·Karina OganezovaLindsey R Baden
Mar 12, 2021·The FEBS Journal·Sneha RatnapriyaAlon Herschhorn

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Methods Mentioned

BETA
RSA

Software Mentioned

COMPASS
Sieve

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