Poxvirus membrane biogenesis

Virology
Bernard Moss

Abstract

Poxviruses differ from most DNA viruses by replicating entirely within the cytoplasm. The first discernible viral structures are crescents and spherical immature virions containing a single lipoprotein membrane bilayer with an external honeycomb lattice. Because this viral membrane displays no obvious continuity with a cellular organelle, a de novo origin was suggested. Nevertheless, transient connections between viral and cellular membranes could be difficult to resolve. Despite the absence of direct evidence, the intermediate compartment (ERGIC) between the endoplasmic reticulum (ER) and Golgi apparatus and the ER itself were considered possible sources of crescent membranes. A break-through in understanding poxvirus membrane biogenesis has come from recent studies of the abortive replication of several vaccinia virus null mutants. Novel images showing continuity between viral crescents and the ER and the accumulation of immature virions in the expanded ER lumen provide the first direct evidence for a cellular origin of this poxvirus membrane.

References

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Citations

Mar 1, 2016·Cell Reports·Karl J ErlandsonBernard Moss
Jun 7, 2016·Nature Reviews. Microbiology·Madhu Sudhan RavindranBilly Tsai
Jun 25, 2016·Viruses·Inés Romero-Brey, Ralf Bartenschlager
Jul 18, 2016·Seminars in Cell & Developmental Biology·Bernard Moss
Jun 16, 2017·Cellular Microbiology·Cristina SuarezJacomine Krijnse-Locker
Sep 30, 2017·FEMS Microbiology Reviews·Marek CyrklaffMikhail Kudryashev
Dec 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·Andrea S WeisbergBernard Moss
Jun 22, 2018·PLoS Pathogens·Bernard Moss
Aug 3, 2018·Proceedings of the National Academy of Sciences of the United States of America·Damià GarrigaFasséli Coulibaly
Jul 3, 2015·Journal of Virology·Mona C GjessingOle Bendik Dale
Jan 8, 2019·PLoS Pathogens·Yeva Mirzakhanyan, Paul Gershon
Apr 3, 2020·PloS One·Caitlin M O'ConnellPaulo H Verardi
Sep 29, 2020·Frontiers in Immunology·Yue Lu, Leiliang Zhang
Jun 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Prabhat Kumar PathakJunpeng Deng
Mar 6, 2021·Journal of Cell Science·Miguel Hernandez-GonzalezMichael Way

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