Poxvirus-vectored vaccines for rabies--a review

Vaccine
Jacqueline WeyerLouis H Nel

Abstract

Oral rabies vaccination of target reservoir species has proved to be one of the pillars of successful rabies elimination programs. The use of live attenuated rabies virus vaccines has been extensive but several limitations hamper its future use. A recombinant vaccinia-rabies vaccine has also been successfully used for the oral vaccination of several species. Nevertheless, its lack of efficacy in certain important rabies reservoirs and concerns on the use of this potent live virus as vaccine carrier (vector) impair the expansion of its use for new target species and new areas. Several attenuated and host-restricted poxvirus alternatives, which supposedly offer enhanced safety, have been investigated. Once again, efficacy in certain target species and innocuity through the oral route remain major limitations of these vaccines. Alternative recombinant vaccines using adenovirus as an antigen delivery vector have been extensively investigated and may provide an important addition to the currently available oral rabies vaccine repertoire, but are not the primary subject of this review.

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Citations

Sep 24, 2010·Future Microbiology·Clement A Meseda, Jerry P Weir
Nov 12, 2010·Journal of Virology·Christoph Wirblich, Matthias J Schnell
Sep 8, 2015·Vaccines·Rebecca J Loomis, Philip R Johnson
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Mar 26, 2013·Vaccine·Matthew G Cottingham, Miles W Carroll
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Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·William P RobinsJohn J Mekalanos
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Mar 8, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Danielle Soares de Oliveira Daian E SilvaFlávio Guimarães Da Fonseca

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