PMID: 701664Nov 1, 1978Paper

Poylmerized whole ragweed: an improved method of immunotherapy

The Journal of Allergy and Clinical Immunology
E BacalR Patterson

Abstract

A single-blind study compared the effectiveness of glutaraldehyde-treated polymerized ragweed with nonpolymerized monomeric ragweed. These studies are an extension of those previously reported for polymerized AgE using a readily available ragweed preparation containing all ragweed antigens. Nineteen ragweed-sensitive patients were randomized into 2 groups; 10 received the polymerized form and 9 received the monomeric form. Four parameters were followed: serum-specific IgE against antigen E, total blocking antibody against antigen E, local and systemic reactions to injection therapy, and symptom score indices. Pretreatment levels of antigen E--specific IgE and blocking antibody activity were similar in both groups. After a total of 15,000 protein nitrogen units (PNU) had been given, blocking antibody activity in the monomer group rose from a mean of 170 ng AgE bound per ml to a mean of 2,813. The rise in blocking antibody activity in the polymer group was from a mean of 181 ng AgE bound per ml to 1,574. At 15,000 PNU, blocking antibody activity levels were not statistically different in the 2 groups. After 1 year of treatment, no consistent decrease in postseasonal specific IgE rise could be shown in either group. Forty times le...Continue Reading

References

Feb 1, 1976·The Journal of Allergy and Clinical Immunology·R Patterson, I M Suszko
Apr 1, 1979·The Journal of Allergy and Clinical Immunology·C R ZeissR Patterson
Jan 1, 1978·The Journal of Allergy and Clinical Immunology·R PattersonE Bacal
Nov 18, 1976·The New England Journal of Medicine·W J MetzgerD Levitz
Feb 1, 1971·The Journal of Clinical Investigation·D A LevyK Ishizaka
Feb 1, 1973·The Journal of Clinical Investigation·L M LichtensteinB M Hill
Mar 1, 1971·Canadian Journal of Biochemistry·B W Griffiths, R Brunet
Mar 1, 1964·Biochemistry·T P KINGJ T CONNELL

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Citations

Jan 1, 1982·Journal of Clinical Immunology·S G HendrixI M Suszko
Dec 1, 1980·The Journal of Allergy and Clinical Immunology·R PattersonJ J Pruzansky
Jan 1, 1980·The Journal of Allergy and Clinical Immunology·J F KellyI M Suszko
Jun 1, 1997·Allergy·A W Wheeler, K J Drachenberg
Apr 1, 1979·The Journal of Allergy and Clinical Immunology·C R ZeissR Patterson
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M A CalderonS Durham
Aug 1, 1983·The Journal of Allergy and Clinical Immunology·R PattersonM A Shaughnessy

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