PP1 Phosphatase Complexes: Undruggable No Longer

Cell
Paola Vagnarelli, Dario R Alessi

Abstract

The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.

Citations

Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shailendra Kumar Dhar DwivediResham Bhattacharya
Oct 11, 2020·Trends in Parasitology·Jamal KhalifeChristine Pierrot
Apr 30, 2020·Biochemistry·Victor A BeaumontJ Patrick Loria

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